ReviewAging cell2009
Hot topics in aging research: protein translation, 2009.
Review in Aging cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations.Mechanisms of ageing and development · 2012Trial
- Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation.PLoS biology · 2025Article
- Cytoplasmic and mitochondrial aminoacyl-tRNA synthetases differentially regulate lifespan iniScience · 2022Article
- Transcriptomic Signatures of Ageing Vary in Solitary and Social Forms of an Orchid Bee.Genome biology and evolution · 2021Article
- Multifaceted deregulation of gene expression and protein synthesis with age.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.Oxidative medicine and cellular longevity · 2020Article
- Mechanisms by which PE21, an extract from the white willowOncotarget · 2019Article
- Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury.Aging and disease · 2019Review
- Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast.Translational medicine of aging · 2019Article
- Protein synthesis and quality control in aging.Aging · 2018Review
- Digital Gene Expression Profiling Analysis of Aged Mice under Moxibustion Treatment.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Nucleolar expansion and elevated protein translation in premature aging.Nature communications · 2017Article
- Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.The Journal of biological chemistry · 2016Article
- Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.Aging cell · 2016Article
- The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time.PloS one · 2016Article
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- Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation.Aging cell · 2014Article
- AMPK at the nexus of energetics and aging.Cell metabolism · 2014Review
- Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations.Protein & cell · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the last few years, links between regulation of mRNA translation and aging have been firmly established in invertebrate model organisms. This year, a possible relationship between mRNA translation and aging in mammals has been established with the report that rapamycin increases lifespan in mice. Other significant findings have connected translation control with other known longevity pathways and provided fodder for mechanistic hypotheses. Here, we summarize advances in this emerging field and raise questions for future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.