ReviewCurrent medicinal chemistry2009
Losartan chemistry and its effects via AT1 mechanisms in the kidney.
Review in Current medicinal chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Assisted evaluation of aniline'sRSC advances · 2026Article
- Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target.Biogerontology · 2024Review
- Spatial and single-cell transcriptome analysis reveals changes in gene expression in response to drug perturbation in rat kidney.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19.Scientific reports · 2021Article
- Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.Science translational medicine · 2021Article
- Effect of Oral Losartan on Orthobiologics: Implications for Platelet-Rich Plasma and Bone Marrow Concentrate-A Rabbit Study.International journal of molecular sciences · 2020Article
- Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.BMJ open sport & exercise medicine · 2020Article
- Effects of Xuesaitong on the Pharmacokinetics of Losartan: AnEvidence-based complementary and alternative medicine : eCAM · 2019Article
- High-salt diets during pregnancy affected fetal and offspring renal renin-angiotensin system.The Journal of endocrinology · 2013Article
- Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation.Journal of the American Society of Nephrology : JASN · 2012Article
- Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.Peptides · 2011Article
- Changed salt appetite and central angiotensin II-induced cellular activation in rat offspring following hypoxia during fetal stages.Peptides · 2010Article
- Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia.American journal of nephrology · 2010Article
- Cardiovascular effects of losartan and its relevant clinical application.Current medicinal chemistry · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Besides the importance of the renin-angiotensin system (RAS) in the circulation and other organs, the local RAS in the kidney has attracted a great attention in research in last decades. The renal RAS plays an important role in the body fluid homeostasis and long-term cardiovascular regulation. All major components and key enzymes for the establishment of a local RAS as well as two important angiotensin II (Ang II) receptor subtypes, AT1 and AT2 receptors, have been confirmed in the kidney. In additional to renal contribution to the systemic RAS, the intrarenal RAS plays a critical role in the regulation of renal function as well as in the development of kidney disease. Notably, kidney AT1 receptors locating at different cells and compartments inside the kidney are important for normal renal physiological functions and abnormal pathophysiological processes. This mini-review focuses on: 1) the local renal RAS and its receptors, particularly the AT1 receptor and its mechanisms in physiological and pathophysiological processes; and 2) the chemistry of the selective AT1 receptor blocker, losartan, and the potential mechanisms for its actions in the renal RAS-mediated disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.