ArticleProteomics. Clinical applications2008
The Urine Proteome as a Biomarker of Radiation Injury: Submitted to Proteomics- Clinical Applications Special Issue: "Renal and Urinary Proteomics (Thongboonkerd)"
Article in Proteomics. Clinical applications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review.PloS one · 2018Pooled it
- Investigation of serum proteome homeostasis during radiation therapy by a quantitative proteomics approach.Bioscience reports · 2019Trial
- Early diagnosis of radiation-induced renal injury: from lagging indicators to multimodal, pre-fibrotic detection.Frontiers in cell and developmental biology · 2026Review
- Early proteomic response in thyroid gland after 131I administration in female Balb/c mice.Radiation protection dosimetry · 2025Article
- Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study.Frontiers in physiology · 2024Article
- A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice.Pharmaceuticals (Basel, Switzerland) · 2017Article
- Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow.International journal of radiation oncology, biology, physics · 2016Article
- A study on the effect of the internal exposure to (210)Po on the excretion of urinary proteins in rats.Radiation and environmental biophysics · 2016Article
- Gene expression signature in mouse thyroid tissue after (131)I and (211)At exposure.EJNMMI research · 2015Article
- The novel diagnostic biomarkers for focal segmental glomerulosclerosis.International journal of nephrology · 2014Article
- Coupling of epithelial Na+ and Cl- channels by direct and indirect activation by serine proteases.American journal of physiology. Cell physiology · 2012Article
- Novel serum proteomic signatures in a non-human primate model of retinal injury.Molecular vision · 2011Article
- Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics.Journal of translational medicine · 2010Article
- The urine proteome for radiation biodosimetry: effect of total body vs. local kidney irradiation.Health physics · 2010Article
- Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.Radiation research · 2010Article
- Low cost, scalable proteomics data analysis using Amazon's cloud computing services and open source search algorithms.Journal of proteome research · 2009Article
- Proteomic Profiling for Serum Biomarkers in Mice Exposed to Ionizing Radiation.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Terrorist attacks or nuclear accidents could expose large numbers of people to ionizing radiation, and early biomarkers of radiation injury would be critical for triage, treatment and follow-up of such individuals. However, no such biomarkers have yet been proven to exist. We tested the potential of high throughput proteomics to identify protein biomarkers of radiation injury after total body X-ray irradiation in a rat model. Subtle functional changes in the kidney are suggested by an increased glomerular permeability for macromolecules measured within 24 hours after TBI. Ultrastructural changes in glomerular podocytes include partial loss of the interdigitating organization of foot processes. Analysis of urine by LC-MS/MS and 2D-GE showed significant changes in the urine proteome within 24 hours after TBI. Tissue kallikrein 1-related peptidase, cysteine proteinase inhibitor cystatin C and oxidized histidine were found to be increased while a number of proteinase inhibitors including kallikrein-binding protein and albumin were found to be decreased post-irradiation. Thus, TBI causes immediately detectable changes in renal structure and function and in the urinary protein profile. This suggests that both systemic and renal changes are induced by radiation and it may be possible to identify a set of biomarkers unique to radiation injury.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.