ArticleExperimental & molecular medicine2009
LIN28B confers radio-resistance through the posttranscriptional control of KRAS.
Article in Experimental & molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer.EMBO reports · 2024Article
- Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer.Molecular biomedicine · 2023Article
- The role of LIN28B in tumor progression and metastasis in solid tumor entities.Oncology research · 2023Review
- Evaluating the role of propolis and bee venom on the oxidative stress induced by gamma rays in rats.Scientific reports · 2022Article
- MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance.International journal of molecular sciences · 2020Article
- MicroRNA-125a-5p modulates radioresistance in LTEP-a2 non-small cell lung cancer cells by targeting SIRT7.Cancer biomarkers : section A of Disease markers · 2020Article
- From basic researches to new achievements in therapeutic strategies of KRAS-driven cancers.Cancer biology & medicine · 2019Article
- Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells.Journal of radiation research · 2017Article
- Identifying the miRNA signature associated with survival time in patients with lung adenocarcinoma using miRNA expression profiles.Scientific reports · 2017Article
- The LIN28/let-7 Pathway in Cancer.Frontiers in genetics · 2017Review
- Emergence of miR-34a in radiation therapy.Critical reviews in oncology/hematology · 2017Review
- Regulation of miRNAs affects radiobiological response of lung cancer stem cells.BioMed research international · 2015Review
- Epigenetics of lung cancer.Translational research : the journal of laboratory and clinical medicine · 2015Review
- PSP94 contributes to chemoresistance and its peptide derivative PCK3145 represses tumor growth in ovarian cancer.Oncogene · 2014Article
- MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.Molecular cancer therapeutics · 2014Article
- The potential clinical applications and prospects of microRNAs in lung cancer.OncoTargets and therapy · 2014Review
- LIN28B promotes colon cancer migration and recurrence.PloS one · 2014Article
- MicroRNAs in the ionizing radiation response and in radiotherapy.Current opinion in genetics & development · 2013Review
- Article
- Prognostic and predictive roles of KRAS mutation in colorectal cancer.International journal of molecular sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in microarray, 27 microRNAs were differentially expressed in NCI-H460 (H460) and NCI-H1299 (H1299) cells. Among them, let-7g was down-regulated in radio-resistant H1299 cells, and the level of let-7g was higher in radio-sensitive cells like Caski, H460, and ME180 in qRT-PCR analysis than in radio-resistant cells like A549, H1299, DLD1, and HeLa. Over-expression of let-7g in H1299 cells could suppress the translation of KRAS, and increase the sensitivity to IR. When we knockdown the expression of LIN28B, an upstream regulator of let-7g, the level of mature let-7g was increased in H1299 cells and the sensitivity to IR was also enhanced in LIN28B knockdown cells. From these data, we suggest that LIN28B plays an important role in radiation responses of lung cancer cells through inhibiting let-7g processing and increasing translation of KRAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.