ArticleAmerican journal of respiratory and critical care medicine2009
Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Environmental Concerns for Children with Asthma on the Navajo Nation.Annals of the American Thoracic Society · 2018Pooled it
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.Indoor air · 2020Trial
- Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma.The journal of allergy and clinical immunology. In practice · 2025Review
- Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children.Environmental research · 2025Article
- Outdoor Air Pollution and Pediatric Respiratory Disease.Clinics in chest medicine · 2024Review
- Article
- Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis.The Lancet. Planetary health · 2023Article
- Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice.Scientific reports · 2021Article
- The Respiratory Risks of Ambient/Outdoor Air Pollution.Clinics in chest medicine · 2020Review
- Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin.Particle and fibre toxicology · 2020Article
- Characterization, pro-inflammatory response and cytotoxic profile of bioaerosols from urban and rural residential settings in Pune, India.Environmental pollution (Barking, Essex : 1987) · 2020Article
- A role for TNF-α in alveolar macrophage damage-associated molecular pattern release.JCI insight · 2020Article
- Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes.American journal of respiratory and critical care medicine · 2019Article
- Environmental exposures and mechanisms in allergy and asthma development.The Journal of clinical investigation · 2019Review
- Combining sensor-based measurement and modeling of PMAerosol science and technology : the journal of the American Association for Aerosol Research · 2019Article
- Effectiveness of a portable air cleaner in removing aerosol particles in homes close to highways.Indoor air · 2018Article
- Associations of mobile source air pollution during the first year of life with childhood pneumonia, bronchiolitis, and otitis media.Environmental epidemiology (Philadelphia, Pa.) · 2018Article
- Concentration-dependent effects of PMEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- β-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TThe Journal of allergy and clinical immunology · 2017Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleMurine models demonstrate a synergistic production of reactive oxygen species on coexposure to diesel exhaust particles and endotoxin.
objectivesIt was hypothesized that coexposure to traffic-related particles and endotoxin would have an additive effect on persistent wheezing during early childhood.
methodsPersistent wheezing at age 36 months was assessed in the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk birth cohort. A time-weighted average exposure to traffic-related particles was determined by applying a land-use regression model to the homes, day cares, and other locations where children spent time from birth through age 36 months. Indoor levels of endotoxin were measured from dust samples collected before age 12 months. The relationship between dichotomized (<or>or=75th percentile) traffic-related particle and endotoxin exposure and persistent wheezing, controlling for potential covariates, was examined. MEASUREMENTS AND MAIN
resultsPersistent wheezing at age 36 months was significantly associated with exposure to increased levels of traffic-related particles before age 12 months (OR = 1.75; 95% confidence interval, 1.07-2.87). Coexposure to endotoxin had a synergistic effect with traffic exposure on persistent wheeze (OR = 5.85; 95% confidence interval, 1.89-18.13) after adjustment for significant covariates.
conclusionsThe association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of reactive oxygen species after coexposure to diesel exhaust particles and endotoxin. The effect of early versus later exposure to traffic-related particles, however, remains to be studied because of the high correlation between exposure throughout the first 3 years of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.