ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 144 citations in OpenAlex.
- Effects of Alternating Mild-Cold and Hot Water Immersion on Lower-Leg Blood Flow Following Immersion in Healthy Young Adults.Scandinavian journal of medicine & science in sports · 2026Trial
- Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.Journal of experimental pharmacology · 2024Trial
- Rapid saline infusion and/or drinking enhance skin sympathetic nerve activity components reduced by hypovolaemia and hyperosmolality in hyperthermia.The Journal of physiology · 2018Trial
- Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Acute L-arginine supplementation has no effect on cardiovascular or thermoregulatory responses to rest, exercise, and recovery in the heat.European journal of applied physiology · 2016Trial
- Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Enhancement of growth performance and health status in heat-stressed growing rabbits using alpha-lipoic acid-loaded chitosan nanoparticles.Animal bioscience · 2026Article
- A new perspective on cardiovascular function and dysfunction during endurance exercise: identifying the primary cause of cardiovascular risk.Biology of sport · 2024Article
- Inhibition of superoxide and iNOS augment cutaneous nitric oxide-dependent vasodilation in non-Hispanic black young adults.Physiological reports · 2024Article
- Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction.International journal of cardiology. Heart & vasculature · 2023Article
- Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials.Materials today. Bio · 2023Review
- Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Endothelin A receptor inhibition increases nitric oxide-dependent vasodilation independent of superoxide in non-Hispanic Black young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Women with a history of preeclampsia have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2022Article
- Medical gas plasma-stimulated wound healing: Evidence and mechanisms.Redox biology · 2021Review
- Heat shock protein 90 modulates cutaneous vasodilation during an exercise-heat stress, but not during passive whole-body heating in young women.Physiological reports · 2020Article
- Short-Term Effect of Different Taping Methods on Local Skin Temperature in Healthy Adults.Frontiers in physiology · 2020Article
- Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus.Oxidative medicine and cellular longevity · 2020Article
- Physical Activity and Brain Health.Genes · 2019Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Nitric oxide (NO) participates in the cutaneous vasodilation caused by increased local skin temperature (Tloc) and whole body heat stress in humans. In forearm skin, endothelial NO synthase (eNOS) participates in vasodilation due to elevated Tloc and neuronal NO synthase (nNOS) participates in vasodilation due to heat stress. To explore the relative roles and interactions of these isoforms, we examined the effects of a relatively specific eNOS inhibitor, N(omega)-amino-l-arginine (LNAA), and a specific nNOS inhibitor, N(omega)-propyl-l-arginine (NPLA), both separately and in combination, on skin blood flow (SkBF) responses to increased Tloc and heat stress in two protocols. In each protocol, SkBF was monitored by laser-Doppler flowmetry (LDF) and mean arterial pressure (MAP) by Finapres. Cutaneous vascular conductance (CVC) was calculated (CVC = LDF/MAP). Intradermal microdialysis was used to treat one site with 5 mM LNAA, another with 5 mM NPLA, a third with combined 5 mM LNAA and 5 mM NPLA (Mix), and a fourth site with Ringer only. In protocol 1, Tloc was controlled with combined LDF/local heating units. Tloc was increased from 34 degrees C to 41.5 degrees C to cause local vasodilation. In protocol 2, after a period of normothermia, whole body heat stress was induced (water-perfused suits). At the end of each protocol, all sites were perfused with 58 mM nitroprusside to effect maximal vasodilation for data normalization. In protocol 1, at Tloc = 34 degrees C, CVC did not differ between sites (P > 0.05). LNAA and Mix attenuated CVC increases at Tloc = 41.5 degrees C to similar extents (P < 0.05, LNAA or Mix vs. untreated or NPLA). In protocol 2, in normothermia, CVC did not differ between sites (P > 0.05). During heat stress, NPLA and Mix attenuated CVC increases to similar extents, but no significant attenuation occurred with LNAA (P < 0.05, NPLA or Mix vs. untreated or LNAA). In forearm skin, eNOS mediates the vasodilator response to increased Tloc and nNOS mediates the vasodilator response to heat stress. The two isoforms do not appear to interact during either response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.