ArticleJournal of leukocyte biology2010
Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Hidden attributes of zymosan in the pathogenesis of inflammatory diseases: A tale of the fungal agent.Iranian journal of basic medical sciences · 2023Review
- Article
- Diet-induced obesity in mice impairs host defense againstAmerican journal of physiology. Lung cellular and molecular physiology · 2022Article
- Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity.PloS one · 2020Article
- IL-17A in the Psoriatic Patients' Serum and Plaque Scales as Potential Marker of the Diseases Severity and Obesity.Mediators of inflammation · 2020Article
- Impact of obesity on autoimmune arthritis and its cardiovascular complications.Autoimmunity reviews · 2018Review
- Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice.International journal of molecular sciences · 2016Article
- Interleukin-17A Gene Expression in Morbidly Obese Women.International journal of molecular sciences · 2015Article
- Childhood obesity: immune response and nutritional approaches.Frontiers in immunology · 2015Review
- Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.European journal of immunology · 2014Article
- Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells.PloS one · 2014Article
- Role of T cells in malnutrition and obesity.Frontiers in immunology · 2014Review
- AZD5363 Inhibits Inflammatory Synergy between Interleukin-17 and Insulin/Insulin-Like Growth Factor 1.Frontiers in oncology · 2014Article
- Insulin and IGF1 enhance IL-17-induced chemokine expression through a GSK3B-dependent mechanism: a new target for melatonin's anti-inflammatory action.Journal of pineal research · 2013Article
- Obesity and airway responsiveness: role of TNFR2.Pulmonary pharmacology & therapeutics · 2013Article
- Stress and obesity as risk factors in cardiovascular diseases: a neuroimmune perspective.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension.American journal of clinical and experimental immunology · 2013Article
- Article
- A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation.EMBO molecular medicine · 2012Article
- Role of IL-6 in the resolution of pancreatitis in obese mice.Journal of leukocyte biology · 2012Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
IL-17A is a proinflammatory cytokine critical for host defense and involved in the pathogenesis of autoimmune disorders. Obesity is associated with chronic low-grade inflammation but also with a heightened acute inflammatory response. We investigated the effect of obesity on IL-17A production using the model of ZY-induced peritonitis. Compared with lean controls, administration of ZY induced a significantly exacerbated inflammatory response in obese leptin-deficient ob/ob mice and in mice with diet-induced obesity (DIO). Levels of IL-17A in the peritoneal fluid in response to ZY were elevated significantly in ob/ob and DIO mice compared with lean animals. Reconstitution of ob/ob mice with exogenous leptin did not alter production of IL-17A significantly in response to ZY. Peritoneal cells and adipose tissue obtained from ZY-injected obese mice expressed significantly higher levels of IL-17A mRNA compared with lean mice. Approximately 2% of peritoneal Ly6G(+) neutrophils from ZY-injected obese mice expressed IL-17A protein, compared with 0.2% of cells obtained from lean mice. Neutralization of IL-17 in ob/ob mice inhibited neutrophil recruitment and production of neutrophil-attracting CXC chemokines and IL-6, without affecting macrophage infiltration or levels of IL-10 and the chemokine CCL2. In contrast, neutralization of IL-6 did not affect production of IL-17A or chemokines while reducing production of the acute-phase protein serum amyloid A significantly. These data demonstrate that neutrophil-derived IL-17A is increased in obese mice during acute inflammation and contributes to exacerbation of inflammatory responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.