ArticleGenome research2009
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
131 citing papers in PubMed, 218 citations in OpenAlex.
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- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Sugar-induced cell death is temperature dependent and conserved inMicrobiology spectrum · 2025Article
- Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis.Molecular microbiology · 2025Article
- Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development.Science (New York, N.Y.) · 2025Article
- Discovering the hidden function in fungal genomes.Nature communications · 2024Review
- Evolution and strain diversity advance exploration ofmSphere · 2024Review
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- Annotation and visualization of parasite, fungi and arthropod genomes with Companion.Nucleic acids research · 2024Article
- A highly conserved tRNA modification contributes toMicrobiology spectrum · 2024Article
- Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts.Science (New York, N.Y.) · 2024Article
- Genetic modification ofMicrobiology (Reading, England) · 2024Article
- Oral Candida carriage and resistance against common antifungal agents in hematopoietic stem cell transplantation recipients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Exploring the Biology, Virulence, and General Aspects ofInfection and drug resistance · 2024Review
- Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in α-, β- and γ- TLO gene function.PLoS genetics · 2023Article
- The role of the Mediator complex in fungal pathogenesis and response to antifungal agents.Essays in biochemistry · 2023Review
- Biochemical typing and evaluation of pathogenicity in vulvovaginal isolates of Candida albicans complexBiomedica : revista del Instituto Nacional de Salud · 2023Article
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- Architectural groups of a subtelomeric gene family evolve along distinct paths in Candida albicans.G3 (Bethesda, Md.) · 2022Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 5 countries.
Funding
Abstract
Candida dubliniensis is the closest known relative of Candida albicans, the most pathogenic yeast species in humans. However, despite both species sharing many phenotypic characteristics, including the ability to form true hyphae, C. dubliniensis is a significantly less virulent and less versatile pathogen. Therefore, to identify C. albicans-specific genes that may be responsible for an increased capacity to cause disease, we have sequenced the C. dubliniensis genome and compared it with the known C. albicans genome sequence. Although the two genome sequences are highly similar and synteny is conserved throughout, 168 species-specific genes are identified, including some encoding known hyphal-specific virulence factors, such as the aspartyl proteinases Sap4 and Sap5 and the proposed invasin Als3. Among the 115 pseudogenes confirmed in C. dubliniensis are orthologs of several filamentous growth regulator (FGR) genes that also have suspected roles in pathogenesis. However, the principal differences in genomic repertoire concern expansion of the TLO gene family of putative transcription factors and the IFA family of putative transmembrane proteins in C. albicans, which represent novel candidate virulence-associated factors. The results suggest that the recent evolutionary histories of C. albicans and C. dubliniensis are quite different. While gene families instrumental in pathogenesis have been elaborated in C. albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.