ArticleMolecular biology and evolution2010
Analysis of the immunoglobulin light chain genes in zebra finch: evolutionary implications.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular Drivers of Lymphocyte Organization in Vertebrate Mucosal Surfaces: Revisiting the TNF Superfamily Hypothesis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Immunoglobulin light chain (IGL) genes in torafugu: Genomic organization and identification of a third teleost IGL isotype.Scientific reports · 2017Article
- Characterization of Lamprey BAFF-like Gene: Evolutionary Implications.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- Immunoglobulin light chains in medaka (Oryzias latipes).Immunogenetics · 2013Article
- The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.Genome biology · 2013Article
- Evolution of B cell immunity.Annual review of animal biosciences · 2013Review
- Evolutionary genomics of immunoglobulin-encoding Loci in vertebrates.Current genomics · 2012Article
- Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian species.PloS one · 2012Article
- Comparative genomics and evolution of the alpha-defensin multigene family in primates.Molecular biology and evolution · 2010Article
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Authors and funding
5 authors.
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Abstract
All jawed vertebrates produce immunoglobulins (IGs) as a defense mechanism against pathogens. Typically, IGs are composed of two identical heavy chains (IGH) and two identical light chains (IGL). Most tetrapod species encode more than one isotype of light chains. Chicken is the only representative of birds for which genomic information is currently available and is an exception to the above rule because it encodes only a single IGL isotype (i.e., lambda). Here, we show that the genome of zebra finch, another bird species, encodes a single IGL isotype, that is, lambda, like the chicken. These results strongly suggest that the second isotype (i.e., kappa) present in both reptiles and mammals was lost in a very early stage of bird evolution. Furthermore, we show that both chicken and zebra finch contain a single set of functional variable, joining, and constant region genes and multiple variable region pseudogenes. The latter finding suggests that this type of genomic organization was already present in the common ancestor of these bird species and remained unchanged over a long evolutionary time. This conservation is in contrast with the high levels of variation observed in the mammalian IGL loci. The presence of a single functional variable region gene followed by multiple variable pseudogenes in zebra finch suggest that this species may be generating antibody diversity by a gene conversion-like mechanism like the chicken.
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