ArticleThe Journal of biological chemistry2009
The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Insights from Mass Spectrometry-Based Proteomics onJournal of fungi (Basel, Switzerland) · 2025Review
- HECT domain interaction with ubiquitin binding sites on Tsg101-UEV controls HIV-1 egress, maturation, and infectivity.The Journal of biological chemistry · 2023Article
- A Cycle of Ubiquitination Regulates Adaptor Function of the Nedd4-Family Ubiquitin Ligase Rsp5.Current biology : CB · 2020Article
- Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.The EMBO journal · 2017Article
- The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.Scientific reports · 2017Article
- Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.Molecular and clinical oncology · 2017Article
- Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity.Human molecular genetics · 2016Article
- A family of tetraspans organizes cargo for sorting into multivesicular bodies.Developmental cell · 2015Article
- SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.Oncotarget · 2014Article
- Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response.The Journal of biological chemistry · 2013Article
- Article
- Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.The EMBO journal · 2012Article
- ESCRT-independent budding of HIV-1 gag virus-like particles from Saccharomyces cerevisiae spheroplasts.PloS one · 2012Article
- Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.The Biochemical journal · 2012Article
- Molecular mechanisms of ubiquitin-dependent membrane traffic.Annual review of biophysics · 2011Article
- Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.The Journal of biological chemistry · 2010Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ubiquitin modification of endosomal membrane proteins is a signal for active inclusion into the Multivesicular Body (MVB) pathway, resulting in lysosomal degradation. However, the endosome represents a dynamic site of protein sorting with a majority of proteins destined for recycling, rather than MVB targeting. Substrate recognition by ubiquitin ligases is therefore highly regulated. We have investigated substrate recognition by the Nedd4 ortholog Rsp5 as a model for understanding ligase-substrate interactions. Rsp5 interacts directly with its substrate Cps1 via a novel interaction mode. Perturbation of this mode of interaction revealed a compensatory role for the Rsp5 adaptor Bsd2. These results highlight the ability of Rsp5 to interact with substrates via multiple modalities, suggesting additional mechanisms of regulating this interaction and relevant outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.