ReviewRespiratory physiology & neurobiology2009
Neuromuscular adaptations to respiratory muscle inactivity.
Review in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 57 citations in OpenAlex.
- Motor Neuron Size-Dependent Differences in mRNA Expression of Tropomyosin-Related Kinase Receptor B in Adult Rats.Journal of neurochemistry · 2026Article
- An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025Review
- Routine hypercapnic challenge after cervical spinal hemisection affects the size of phrenic motoneurons.Scientific reports · 2023Article
- Deletion ofeNeuro · 2023Article
- Muscle-specific deletion of the vitamin D receptor in mice is associated with diaphragm muscle weakness.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice.Journal of neurophysiology · 2021Article
- Respiratory Training and Plasticity After Cervical Spinal Cord Injury.Frontiers in cellular neuroscience · 2021Review
- Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?Frontiers in physiology · 2020Article
- Diaphragm muscle sarcopenia into very old age in mice.Physiological reports · 2020Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive physiology · 2019Review
- Diaphragm Muscle Adaptations in Health and Disease.Drug discovery today. Disease models · 2019Article
- Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis.The Journal of comparative neurology · 2018Article
- Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression.Aging · 2017Article
- Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction.Physiological reports · 2017Article
- Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury.Experimental neurology · 2017Review
- Plasticity in respiratory motor neurons in response to reduced synaptic inputs: A form of homeostatic plasticity in respiratory control?Experimental neurology · 2017Review
- A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells.Journal of neuroscience methods · 2016Article
- TrkB gene therapy by adeno-associated virus enhances recovery after cervical spinal cord injury.Experimental neurology · 2016Article
- Functional impact of diaphragm muscle sarcopenia in both male and female mice.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice.Muscle & nerve · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cervical spinal cord injury results in significant functional impairment. It is important to understand the neuroplasticity in response to inactivity of respiratory muscles in order to prevent any associated effects that limit functional recovery. Recent studies have examined the mechanisms involved in inactivity-induced neuroplasticity of diaphragm motor units. Both spinal hemisection at C2 (C2HS) and tetrodotoxin (TTX)-induced phrenic nerve blockade result in diaphragm paralysis and inactivity of axon terminals. However, phrenic motoneurons are inactive with C2HS but remain active after TTX. Diaphragm muscle fibers ipsilateral to C2HS display minimal changes post-injury. Neuromuscular transmission is enhanced following C2HS but impaired following TTX. Synaptic vesicle pool size at diaphragm neuromuscular junctions increases after C2HS, but decreases after TTX. Thus, inactivity-induced neuromuscular plasticity reflects specific adaptations that depend on inactivity at the motoneuron rather than at axon terminals or muscle fibers. These results indicate that neuromuscular transmission and functional properties of diaphragm fibers can be maintained after spinal cord injury, providing a substrate for functional recovery and/or specific therapeutic approaches such as phrenic pacing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.