Evidence map›Paper›PMID 19743894›Full record

ReviewExpert opinion on drug delivery2009

Nanoparticles for biomedical imaging.

Satish K Nune, Padmaja Gunda, Praveen K Thallapally, Ying-Ying Lin, M Laird Forrest, Cory J Berkland

Abstract readReview
In one paragraph

Review in Expert opinion on drug delivery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed.

  1. Advances in Nanotoxicology: Health and Safety.Nanomaterials (Basel, Switzerland) · 2026
    Article
  2. Luminescent protein-gold compounds for nanomedicine.Nanomedicine (London, England) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Green Synthesis of Metal Nanoparticles UsingNanotechnology, science and applications · 2025
    Review
  8. Precision Oncology: Advances in Drug Delivery and Imaging.Recent advances in drug delivery and formulation · 2025
    Review
  9. Biosynthesized zinc oxide nanoparticles fromFrontiers in pharmacology · 2025
    Article
  10. Article
  11. Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles.bioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Satish K NunePacific Northwest National Laboratory, 902 Battelle Boulevard, PO Box 999, MSIN K6-81, Richland, WA 99352, USA. satish.nune@pnl.gov
Padmaja Gunda
Praveen K Thallapally
Ying-Ying Lin
M Laird Forrest
Cory J Berkland

Funding

XRAY CRYSTALLOGRAPHY CORE (JANUARY 1 - JUNE 30, 2005)P20RR016443 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VINES, CHARLOTTE M · 2001 to 2010
$21.3M
WEIGHT CONTROL, CELL SIGNALING AND CANCER PREVENTIONP20RR015563 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI ZUFFEREY, RACHEL · 2000 to 2009
$20.1M
Targeted polymeric nanocarriers for combination therapy of prostate cancerR21CA132033 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI FORREST, MARCUS LAIRD · 2008 to 2009
$373k
Nanoparticle targeting of ICAM-1 as a potential treatment for Rheumatoid ArthritiR03AR054035 · NIAMS · UNIVERSITY OF KANSAS LAWRENCE · PI BERKLAND, CORY · 2007 to 2009
$205k
NCI NIH HHS R21 CA132033NCRR NIH HHS P20 RR015563NCRR NIH HHS P20 RR016443NIAMS NIH HHS R03 AR054035
6 · The paper itself

Abstract

backgroundSynthetic nanoparticles are emerging as versatile tools in biomedical applications, particularly in the area of biomedical imaging. Nanoparticles 1 - 100 nm in diameter have dimensions comparable to biological functional units. Diverse surface chemistries, unique magnetic properties, tunable absorption and emission properties, and recent advances in the synthesis and engineering of various nanoparticles suggest their potential as probes for early detection of diseases such as cancer. Surface functionalization has expanded further the potential of nanoparticles as probes for molecular imaging.

objectiveTo summarize emerging research of nanoparticles for biomedical imaging with increased selectivity and reduced nonspecific uptake with increased spatial resolution containing stabilizers conjugated with targeting ligands.

methodsThis review summarizes recent technological advances in the synthesis of various nanoparticle probes, and surveys methods to improve the targeting of nanoparticles for their application in biomedical imaging.

conclusionStructural design of nanomaterials for biomedical imaging continues to expand and diversify. Synthetic methods have aimed to control the size and surface characteristics of nanoparticles to control distribution, half-life and elimination. Although molecular imaging applications using nanoparticles are advancing into clinical applications, challenges such as storage stability and long-term toxicology should continue to be addressed.

Indexed as

NanoparticlesAnimalsHumansMolecular ImagingNanotechnologyOrgan SpecificitySurface Properties

Identifiers

PMID19743894
PMCPMC3097035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.