ArticleNano letters2009
Super-resolution laser scanning microscopy through spatiotemporal modulation.
Article in Nano letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Optical sectioning methods in three-dimensional bioimaging.Light, science & applications · 2025Review
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Virtually structured detection enables super-resolution ophthalmoscopy of rod and cone photoreceptors in human retina.Quantitative imaging in medicine and surgery · 2021Article
- Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Virtual single-pixel imaging-based deconvolution method for spatial resolution improvement in wide-field fluorescence microscopy.Biomedical optics express · 2020Article
- Imaging neuronal structure dynamics using 2-photon super-resolution patterned excitation reconstruction microscopy.Journal of biophotonics · 2018Article
- Three-dimensional wide-field pump-probe structured illumination microscopy.Optics express · 2017Article
- In vivo super-resolution retinal imaging through virtually structured detection.Journal of biomedical optics · 2016Article
- Virtual k-Space Modulation Optical Microscopy.Physical review letters · 2016Article
- Recent advances in imaging subcellular processes.F1000Research · 2016Review
- Rapid super-resolution line-scanning microscopy through virtually structured detection.Optics letters · 2015Article
- Super-resolution two-photon microscopy via scanning patterned illumination.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Fabrication of three-dimensional multi-protein microstructures for cell migration and adhesion enhancement.Biomedical optics express · 2015Article
- Super-Resolution Scanning Laser Microscopy Based on Virtually Structured Detection.Critical reviews in biomedical engineering · 2015Review
- Highly resolved intravital striped-illumination microscopy of germinal centers.Journal of visualized experiments : JoVE · 2014Article
- Breaking diffraction limit of lateral resolution in optical coherence tomography.Quantitative imaging in medicine and surgery · 2013Article
- Super-resolution scanning laser microscopy through virtually structured detection.Biomedical optics express · 2013Article
- Structured interference optical coherence tomography.Optics letters · 2012Article
- High-resolution intravital microscopy.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Super-resolution optical microscopy has attracted great interest among researchers in many fields, especially in biology where the scale of physical structures and molecular processes fall below the diffraction limit of resolution for light. As one of the emerging techniques, structured illumination microscopy can double the resolution by shifting unresolvable spatial frequencies into the pass-band of the microscope through spatial frequency mixing with a wide-field structured illumination pattern. However, such a wide-field scheme typically can only image optically thin samples and is incompatible with multiphoton processes such as two-photon fluorescence, which require point scanning with a focused laser beam. Here, we propose two new super-resolution schemes for laser scanning microscopy by generalizing the concept of a spatially nonuniform imaging system. One scheme, scanning patterned illumination (SPIN) microscopy, employs modulation of the excitation combined with temporally cumulative imaging by a nondescanned array detector. The other scheme, scanning patterned detection (SPADE) microscopy, utilizes detection modulation together with spatially cumulative imaging, in this case by a nondescanned single-element detector. When combined with multiphoton excitation, both schemes can image thick samples with three-dimensional optical sectioning and much improved resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.