ArticleBiomacromolecules2009
Bioreducible hyperbranched poly(amido amine)s for gene delivery.
Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 114 citations in OpenAlex.
- Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery.Molecular therapy. Nucleic acids · 2023Review
- Cationic Polymers as Transfection Reagents for Nucleic Acid Delivery.Pharmaceutics · 2023Review
- Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme.Current drug metabolism · 2022Review
- Biodegradable Polymers for Gene-Delivery Applications.International journal of nanomedicine · 2020Review
- Disulfide-containing Macromolecules for Therapeutic Delivery.Israel journal of chemistry · 2020Article
- Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing.International journal of nanomedicine · 2020Review
- Controlled Synthesis of Linear Polyamidoamino Acids.Polymers · 2019Article
- Layer-by-layer DNA films incorporating highly transfecting bioreducible poly(amido amine) and polyethylenimine for sequential gene delivery.International journal of nanomedicine · 2018Article
- Targeted polymeric nanoparticles for cancer gene therapy.Journal of drug targeting · 2015Review
- Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures.International journal of nanomedicine · 2015Review
- Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor.Biomaterials · 2014Article
- Microfluidic preparation of polymer-nucleic acid nanocomplexes improves nonviral gene transfer.Scientific reports · 2013Article
- Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations.Biomaterials · 2013Article
- Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy.Biomaterials · 2013Article
- Cyclam-based polymeric copper chelators for gene delivery and potential PET imaging.Biomacromolecules · 2012Article
- Dual-function CXCR4 antagonist polyplexes to deliver gene therapy and inhibit cancer cell invasion.Angewandte Chemie (International ed. in English) · 2012Article
- Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2012Article
- Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery.International journal of pharmaceutics · 2012Article
- Article
- A comparative study of three ternary complexes prepared in different mixing orders of siRNA/redox-responsive hyperbranched poly (amido amine)/hyaluronic acid.International journal of nanomedicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A series of reducible hyperbranched poly(amido amine)s (RHB) with high transfection efficiency were designed and synthesized as nonviral gene delivery vectors. The polycations were synthesized by Michael addition copolymerization of N,N-dimethylaminodipropylenetriamine (DMDPTA) and two bisacrylamide monomers N,N'-hexamethylene bisacrylamide (HMBA) and N,N'-cystamine bisacrylamide (CBA). The density of disulfide linkages in the synthesized hyperbranched polymers was tuned by varying the feed molar ratio of the bisacrylamide monomers. The results demonstrate that disulfide content in RHB controls the molecular weight of the polycation degradation products, ease of polyplex disassembly, polycation cytotoxicity, and polyplex transfection activity. Due to their lower cytotoxicity, polyplexes based on reducible polycations could be used safely in a wider range of DNA doses than nonreducible controls. As a result, significantly increased transfection activity is achieved with optimized formulations of reducible polyplexes compared with nonreducible controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.