ArticleIndian journal of psychiatry2009
The prevention and treatment of cognitive decline and dementia: An overview of recent research on experimental treatments.
Article in Indian journal of psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis.Systematic reviews · 2020Pooled it
- Comparing the effect of individual and group cognitive-motor training on reconstructing subjective well-being and quality of life in older males, recovered from the COVID-19.Cognitive processing · 2023Trial
- Cognitive stimulation in a-MCI: an experimental study.American journal of Alzheimer's disease and other dementias · 2012Trial
- Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway.Brain and behavior · 2026Article
- Advancing Alzheimer's Therapy: Computational strategies and treatment innovations.IBRO neuroscience reports · 2025Review
- Predicting poor self-management behaviors in adults with newly diagnosed COPD: based on the information-motivation-behavioral skills model.BMC public health · 2025Article
- Translation and validation of the Saint Louis University Mental Status (SLUMS) Exam for older adults in Thailand: The SLUMS-Thai.Belitung nursing journal · 2025Article
- Advancing Alzheimer's Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients.Cells · 2023Review
- Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability.Journal of ginseng research · 2022Article
- Review
- Factors Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes: A Cohort Study.Cureus · 2022Article
- The Differential Effects of Tai Chi vs. Brisk Walking on Cognitive Function Among Individuals Aged 60 and Greater.Frontiers in human neuroscience · 2022Article
- Visual Function and Visual Perception among Senior Citizens with Mild Cognitive Impairment in Taiwan.Healthcare (Basel, Switzerland) · 2021Article
- Treatment evaluation of Kami Guibi-tang on participants with amnestic mild cognitive impairment using magnetic resonance imaging on brain metabolites, gamma-aminobutyric acid, and cerebral blood flow.Journal of applied clinical medical physics · 2021Article
- Dementia and Cognitive Decline in Older Adulthood: Are Agricultural Workers at Greater Risk?The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Drug therapies for chronic conditions and risk of Alzheimer's disease and related dementias: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Diet Associated with Inflammation and Alzheimer's Disease.Journal of Alzheimer's disease reports · 2019Review
- Synergistic Neuroprotective Effect ofInternational journal of molecular sciences · 2019Article
- Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis.Clinical and translational gastroenterology · 2018Article
- Dissecting the Potential Roles ofFrontiers in aging neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevention and treatment of cognitive impairment in the elderly has assumed increasing importance in an aging population. This article presents a qualitative review of recent research on experimental interventions for the prevention and treatment of mild cognitive impairment and Alzheimer's disease in elderly subjects. Interventions addressed range from lifestyle measures to pharmacological treatments. Epidemiological studies suggest that dietary measures, physical exercise, and mental activity may reduce the risk of cognitive impairment and Alzheimer's disease in elderly subjects. Statins may protect against incident dementia, and lithium may convey similar benefits to bipolar patients. Ginkgo appears ineffective as a primary preventive measure. Donepezil but not Vitamin E may benefit persons with mild cognitive impairment. Experimental treatments potentially useful for Alzheimer's disease include dimebon, PBT2 and etanercept; the safety and efficacy of the Alzheimer's vaccine remains to be proven, and growth hormone secretagogue and tarenflurbil are likely ineffective. Herbal treatments merit study in elderly subjects with cognitive syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.