Evidence map›Paper›PMID 19742179›Full record

ReviewInternational journal of molecular sciences2009

Hyaluronan benzyl ester as a scaffold for tissue engineering.

Vincenzo Vindigni, Roberta Cortivo, Laura Iacobellis, Giovanni Abatangelo, Barbara Zavan

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Electrochemical Benzylic C(spOrganic letters · 2022
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  18. Investigation of potential injectable polymeric biomaterials for bone regeneration.Journal of biomedical materials research. Part A · 2013
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vincenzo VindigniUnit of Plastic and Reconstructive Surgery, University of Padova, Via Giustiniani 2, 35100 Padova, Italy.
Roberta CortivoDept of Histology, Microbiology and Biomedical Technologies, University of Padova Viale G. Colombo 3, 35131 Padova, Italy.
Laura IacobellisDept of Histology, Microbiology and Biomedical Technologies, University of Padova Viale G. Colombo 3, 35131 Padova, Italy.
Giovanni AbatangeloDept of Histology, Microbiology and Biomedical Technologies, University of Padova Viale G. Colombo 3, 35131 Padova, Italy.
Barbara ZavanDept of Histology, Microbiology and Biomedical Technologies, University of Padova Viale G. Colombo 3, 35131 Padova, Italy.ORCID 0000-0002-4779-4456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineering is a multidisciplinary field focused on in vitro reconstruction of mammalian tissues. In order to allow a similar three-dimensional organization of in vitro cultured cells, biocompatible scaffolds are needed. This need has provided immense momentum for research on "smart scaffolds" for use in cell culture. One of the most promising materials for tissue engineering and regenerative medicine is a hyaluronan derivative: a benzyl ester of hyaluronan (HYAFF). HYAFF can be processed to obtain several types of devices such as tubes, membranes, non-woven fabrics, gauzes, and sponges. All these scaffolds are highly biocompatible. In the human body they do not elicit any adverse reactions and are resorbed by the host tissues. Human hepatocytes, dermal fibroblasts and keratinocytes, chondrocytes, Schwann cells, bone marrow derived mesenchymal stem cells and adipose tissue derived mesenchymal stem cells have been successfully cultured in these meshes. The same scaffolds, in tube meshes, has been applied for vascular tissue engineering that has emerged as a promising technology for the design of an ideal, responsive, living conduit with properties similar to that of native tissue.

Indexed as

Biocompatible MaterialsTissue EngineeringTissue ScaffoldsAnimalsHumansHyaluronic AcidBiocompatible MaterialsHyaluronic Acidhyaluronic acid benzyl esterHYAFFhyaluronantissue engineering

Identifiers

PMID19742179
PMCPMC2738906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.