ArticleInternational journal of molecular sciences2009
Genistein inhibition of topoisomerase IIalpha expression participated by Sp1 and Sp3 in HeLa cell.
Article in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.Chemistry & biodiversity · 2026Review
- Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition ofTurkish journal of pharmaceutical sciences · 2024Article
- Evolution of Natural Product Scaffolds as Potential Proteasome Inhibitors in Developing Cancer Therapeutics.Metabolites · 2023Review
- Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy.International journal of molecular sciences · 2022Review
- Soy and breast cancer: focus on angiogenesis.International journal of molecular sciences · 2015Review
- In vitro action of flavonoids in the canine malignant histiocytic cell line DH82.Molecules (Basel, Switzerland) · 2013Article
- Anticancer activities of genistein-topotecan combination in prostate cancer cells.Journal of cellular and molecular medicine · 2012Article
- Soy-derived isoflavones inhibit HeLa cell growth by inducing apoptosis.Plant foods for human nutrition (Dordrecht, Netherlands) · 2011Article
- The combination of TRAIL and isoflavones enhances apoptosis in cancer cells.Molecules (Basel, Switzerland) · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genistein (4', 5, 7-trihydroxyisoflavone) is an isoflavone compound obtained from plants that has potential applications in cancer therapy. However, the molecular mechanism of the action of genistein on cancer cell apoptosis is not well known. In this study, we investigated the effect of genistein on topoisomerase II-alpha (Topo IIalpha), an important protein involved in the processes of DNA replication and cell proliferation. The results revealed that inhibition of Topo IIalpha expression through the regulation of Specificity protein 1 and Specificity protein 3 may be one of the reasons for genistein's induction of HeLa cell apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.