Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

38 citing papers in PubMed.

1. Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.Haematologica · 2020
   Trial
2. ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker.Leukemia · 2025
   Article
3. A Peculiar CLL Case with Complex Chromosome 6 Rearrangements and Refinement of All Breakpoints at the Gene Level by Genomic Array: A Case Report.Journal of clinical medicine · 2023
   Article
4. Five Percent Variant Allele Frequency Is a Reliable Reporting Threshold forHemaSphere · 2022
   Article
5. Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.Nature communications · 2021
   Article
6. Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact.Blood · 2019
   Article
7. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.Haematologica · 2016
   Article
8. Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.American journal of translational research · 2016
   Article
9. Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.Genes, chromosomes & cancer · 2015
   Article
10. Recurrent mutations refine prognosis in chronic lymphocytic leukemia.Leukemia · 2015
    Article
11. Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution.Haematologica · 2015
    Review
12. microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.Epigenetics · 2014
    Article
13. On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort.Leukemia · 2014
    Article
14. Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia.Leukemia · 2014
    Article
15. Copy neutral loss of heterozygosity in 20q in chronic lymphocytic leukemia/small lymphocytic lymphoma.Cancer genetics · 2014
    Article
16. Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling.Molecular cytogenetics · 2014
    Article
17. Genetic abnormalities in chronic lymphocytic leukemia: where we are and where we go.BioMed research international · 2014
    Review
18. Republished: Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime.Postgraduate medical journal · 2013
    Article
19. The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia.Oncogene · 2013
    Review
20. Clinical implications of the molecular genetics of chronic lymphocytic leukemia.Haematologica · 2013
    Review

Corrections and comments

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Authors and funding

17 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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