ArticleInvestigative ophthalmology & visual science2010
Developmental corneal innervation: interactions between nerves and specialized apical corneal epithelial cells.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Neuroanatomy of Adult and Aging Chicken Cornea.Current eye research · 2022Article
- Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration.Frontiers in cellular neuroscience · 2020Article
- Corneal pain and experimental model development.Progress in retinal and eye research · 2019Review
- Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System.Scientific reports · 2018Article
- Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model.Metabolic brain disease · 2018Article
- Developmental analysis of SV2 in the embryonic chicken corneal epithelium.Experimental eye research · 2018Article
- The Corneal Epithelial Barrier and Its Developmental Role in Isolating Corneal Epithelial and Conjunctival Cells From One Another.Investigative ophthalmology & visual science · 2017Article
- In Vivo Confocal Microscopy of Corneal Nerves in Health and Disease.The ocular surface · 2017Review
- MyD88 contribution to ocular surface homeostasis.PloS one · 2017Article
- Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Neuropeptide substance P and the immune response.Cellular and molecular life sciences : CMLS · 2016Review
- Neuroanatomy and Neurochemistry of Mouse Cornea.Investigative ophthalmology & visual science · 2016Article
- Article
- The PEDF Neuroprotective Domain Plus DHA Induces Corneal Nerve Regeneration After Experimental Surgery.Investigative ophthalmology & visual science · 2015Article
- Effects of polysialic acid on sensory innervation of the cornea.Developmental biology · 2015Article
- Developmental regulation of trigeminal TRPA1 by the cornea.Investigative ophthalmology & visual science · 2014Article
- Wounding the cornea to learn how it heals.Experimental eye research · 2014Review
- Wounded embryonic corneas exhibit nonfibrotic regeneration and complete innervation.Investigative ophthalmology & visual science · 2013Article
- Corneal sulfated glycosaminoglycans and their effects on trigeminal nerve growth cone behavior in vitro: roles for ECM in cornea innervation.Investigative ophthalmology & visual science · 2012Article
- NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing.The American journal of pathology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe corneal epithelium is one of the most highly innervated structures in the body, and proper innervation is necessary for corneal maintenance and sensation. However, little is known about how these nerves function and how innervation occurs developmentally. The authors have examined certain aspects of corneal innervation in the developing chicken embryo.
methodsDiI was used to determine the source of the neurons responsible for innervating the cornea. Immunohistochemistry, electron microscopy, and immunoelectron microscopy were used to examine corneal innervation and the relationships that develop between nerves and corneal epithelial cells.
resultsCorneal nerves in the embryonic chicken originate entirely from the ophthalmic lobe of the trigeminal ganglion. Within the cornea the nerves interact with apical corneal epithelial (ACE) cells to form specialized structures that are synapse-like because they contain accumulations of vesicles and have the SV2 synaptic vesicle protein. These ACE cells themselves have unique characteristics, including transient expression of the neuronal isoform of class III beta-tubulin and formation of extensive intercellular channels and clefts that contain these specialized synapse-like structures and nerves; in addition, they are mitotically active. Given that these ACE cells react with a monoclonal antibody against this neuronal isoform of beta-tubulin (the TuJ-1 antibody), we have termed them TuJ-1(+)ACE cells.
conclusionsDuring avian corneal development the nerves make close associations with a specialized type of ACE cell. There they form synapse-like structures, suggesting that not all nerves within the CE terminate as free nerve endings.
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Registered trials
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