ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- The role of prostanoids in the retina and optic nerve in health and disease.Progress in retinal and eye research · 2026Review
- IK Channel Confers Fine-tuning of Rod Bipolar Cell Excitation and Synaptic Transmission in the Retina.Function (Oxford, England) · 2025Article
- Adenosine receptor signalling in Alzheimer's disease.Purinergic signalling · 2022Review
- Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex.Frontiers in neural circuits · 2022Review
- The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine AInternational journal of molecular sciences · 2020Review
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Adenosine AThe Journal of physiology · 2018Article
- AMolecular neurobiology · 2017Review
- Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.Nature communications · 2017Article
- Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons.Nature communications · 2017Article
- Effect of adenosine on GLAST expression in the retina of a chronic ocular hypertension rat model.Experimental and therapeutic medicine · 2015Article
- Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye.Investigative ophthalmology & visual science · 2015Article
- Extraction (DSX) from Erigeron breviscapus modulates outward potassium currents in rat retinal ganglion cells.International journal of ophthalmology · 2015Article
- An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.PloS one · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Assessment of glial function in the in vivo retina.Methods in molecular biology (Clifton, N.J.) · 2012Article
- The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine is a neuromodulator that activates presynaptic receptors to regulate synaptic transmission and postsynaptic receptors to hyperpolarize neurons. Here, we report that adenosine-induced hyperpolarization of retinal ganglion cells is produced by the activation of A(1) receptors, which initiates a signaling cascade that activates G-protein-coupled inwardly rectifying K(+) (GIRK) channels and small conductance Ca(2+)-activated K(+) (SK) channels. Rat retinal ganglion cells were stimulated by focal ejection of the adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) while cell activity was monitored with whole-cell patch recordings and Ca(2+) imaging. Focal ejections of NECA evoked outward currents in all cells tested and reduced light- and depolarization-induced spiking. The NECA-evoked current was abolished by the A(1) antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) but was unaffected by A(2a), A(2b), and A(3) antagonists, indicating that the response was mediated entirely by A(1) receptors. The GIRK channel blocker rTertiapin-Q diminished the NECA-evoked inhibitory current by 56 +/- 12%, whereas the SK channel blocker apamin decreased the NECA-induced current by 42 +/- 7%. The SK component of the NECA-evoked current coincided with an increase in intracellular Ca(2+) and was blocked by IP(3) receptor antagonists and depletion of internal Ca(2+) stores, suggesting that A(1) receptor activation leads to an increase in IP(3), which then elevates intracellular Ca(2+) and activates SK channels. This A(1)-mediated, prolonged SK channel activation has not been described previously. The coactivation of GIRK and SK channels represents a novel mechanism of adenosine-mediated neuromodulation that could contribute to the regulation of retinal ganglion cell activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.