ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Short trains of theta frequency stimulation enhance CA1 pyramidal neuron excitability in the absence of synaptic potentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- The Effect of Caffeine on Various Forms of Synaptic Plasticity in the CA1 Region of Mouse Hippocampal Slices.Biomolecules · 2026Article
- β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus.Frontiers in synaptic neuroscience · 2024Article
- Behavioral Timescale Cooperativity and Competitive Synaptic Interactions Regulate the Induction of Complex Spike Burst-Dependent Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?Frontiers in cellular neuroscience · 2020Review
- β-Adrenergic enhancement of neuronal excitability in the lateral amygdala is developmentally gated.Journal of neurophysiology · 2018Article
- Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation.Physiological reports · 2017Article
- Differential Regulation of NMDA Receptor-Mediated Transmission by SK Channels Underlies Dorsal-Ventral Differences in Dynamics of Schaffer Collateral Synaptic Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dynamic Regulation of AMPAR Phosphorylation In Vivo Following Acute Behavioral Stress.Cellular and molecular neurobiology · 2016Article
- Associative spike timing-dependent potentiation of the basal dendritic excitatory synapses in the hippocampus in vivo.Journal of neurophysiology · 2016Article
- Homeostatic role of heterosynaptic plasticity: models and experiments.Frontiers in computational neuroscience · 2015Review
- Heterosynaptic plasticity: multiple mechanisms and multiple roles.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Augmented Inhibition from Cannabinoid-Sensitive Interneurons Diminishes CA1 Output after Traumatic Brain Injury.Frontiers in cellular neuroscience · 2014Article
- Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices.Frontiers in synaptic neuroscience · 2011Article
- Frequency-Dependent Changes in NMDAR-Dependent Synaptic Plasticity.Frontiers in computational neuroscience · 2011Article
- Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.PloS one · 2011Article
- More than synaptic plasticity: role of nonsynaptic plasticity in learning and memory.Trends in neurosciences · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although plasticity at excitatory synapses is widely studied as a mechanism for memory formation, less is known about the properties and mechanisms underlying activity-dependent changes in excitability. Using extracellular and intracellular recordings in hippocampal slices, we find that short trains (2-3 s) of Schaffer collateral fiber stimulation delivered at 5 Hz induce a robust and persistent increase in the excitability of CA1 pyramidal cells in the absence of synaptic potentiation. This change in excitability is input specific, NMDA receptor dependent, and is not accompanied by lasting changes in either inhibitory synaptic transmission or somatic excitability. Although many of these properties are similar to those seen in synaptic long-term potentiation (LTP), the increase in CA1 pyramidal cell excitability was not blocked by inhibitors of several protein kinases required for the induction of LTP by theta frequency stimulation. Instead, 5 Hz stimulation-induced changes in neuronal excitability were blocked by inhibitors of the protein phosphatase calcineurin. Together, our results suggest that very brief bouts of theta frequency synaptic activity induce a selective, persistent, and dendritically localized increase in CA1 pyramidal cell excitability that might have an important role in both information storage and metaplasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.