ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Synaptic memory and CaMKII.Physiological reviews · 2023Review
- Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.Molecular neurodegeneration · 2021Article
- Article
- Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Deletion ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.Nature reviews. Neuroscience · 2018Review
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells.Scientific reports · 2017Article
- Review
- IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.Neuron · 2017Article
- NMDA receptor-independent long-term potentiation in hippocampal interneurons.The Journal of physiology · 2017Article
- T-type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular-spiking oriens-alveus interneurons.The Journal of physiology · 2017Article
- Article
- Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.Molecular psychiatry · 2017Article
- Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders.Neural plasticity · 2016Review
- Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.PLoS biology · 2015Article
- Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Modern theories on memory storage have mainly focused on Hebbian long-term potentiation (LTP), which requires coincident activation of presynaptic and postsynaptic neurons for its induction. In addition to Hebbian LTP, the roles of non-Hebbian plasticity have also been predicted by some neuronal network models. However, still only a few pieces of evidence have been presented for the presence of such plasticity. In this study, we show in mouse hippocampal slices that LTP can be induced by postsynaptic repetitive depolarization alone in the absence of presynaptic inputs. The induction was dependent on voltage-dependent calcium channels instead of NMDA receptors (NMDARs), whereas the expression mechanism was shared with conventional NMDAR-dependent LTP. During the potentiation, the amplitude of spontaneous EPSCs was increased, suggesting a novel neuron-wide nature of this form of LTP. Furthermore, we also successfully induced LTP with trains of action potentials, which supported the possible existence of depolarizing pulse-induced LTP in vivo. Based on these findings, we suggest a model in which neuron-wide LTP works in concert with synapse-specific Hebbian plasticity to help information processing in memory formation.
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