ArticleJournal of neurophysiology2009
Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free-Moving Mice.Advanced healthcare materials · 2026Article
- Zwitterionic polymer coating enabled chronic dopamine sensing and electrophysiology recording in free-moving mice.bioRxiv : the preprint server for biology · 2026Article
- Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism.Science advances · 2025Article
- Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets.Neurobiology of disease · 2023Review
- AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures.Brain : a journal of neurology · 2022Article
- Effects of Alcohol Extracts FromFrontiers in nutrition · 2022Article
- Circulating Metabolites as Potential Biomarkers for Neurological Disorders-Metabolites in Neurological Disorders.Metabolites · 2020Article
- TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury.Molecular neurobiology · 2019Article
- Article
- Glucose Transporter Type I Deficiency (G1D) at 25 (1990-2015): Presumptions, Facts, and the Lives of Persons With This Rare Disease.Pediatric neurology · 2015Review
- Mechanisms underlying desynchronization of cholinergic-evoked thalamic network activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury.Nature neuroscience · 2013Article
- Article
- Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.Neuroscience · 2012Article
- Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Review
- GABA metabolism and transport: effects on synaptic efficacy.Neural plasticity · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The generation of prolonged neuronal activity depends on the maintenance of synaptic neurotransmitter pools. The astrocytic glutamate-glutamine cycle is a major mechanism for recycling the neurotransmitters GABA and glutamate. Here we tested the effect of disrupting the glutamate-glutamine cycle on two types of neuronal activity patterns in the thalamus: sleep-related spindles and epileptiform oscillations. In recording conditions believed to induce glutamine scarcity, epileptiform oscillations showed a progressive reduction in duration that was partially reversible by the application of exogenous glutamine (300 muM). Blocking uptake of glutamine into neurons with alpha-(methylamino) isobutyric acid (5 mM) caused a similar reduction in oscillation duration, as did blocking neuronal GABA synthesis with 3-mercaptoproprionic acid (10 muM). However, comparable manipulations did not affect sleep spindles. Together, these results support a crucial role for the glutamate-glutamine cycle in providing the neurotransmitters necessary for the generation of epileptiform activity and suggest potential therapeutic approaches that selectively reduce seizure activity but maintain normal neuronal activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.