ArticleThe Journal of general virology2009
Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response.
Article in The Journal of general virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Exploring the Potential ofViruses · 2024Article
- Detection of Alpha- and Betacoronaviruses in Small Mammals in Western Yunnan Province, China.Viruses · 2023Article
- Review
- Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data.PNAS nexus · 2022Article
- SDAV, the Rat Coronavirus-How Much Do We Know about It in the Light of Potential Zoonoses.Viruses · 2021Review
- Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and Wildlife.Viruses · 2021Review
- Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission.PloS one · 2021Article
- Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective.Animals : an open access journal from MDPI · 2020Review
- The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain.The Journal of biological chemistry · 2020Article
- COVID 19: a clue from innate immunity.Immunologic research · 2020Review
- Coronavirus Pandemic-Therapy and Vaccines.Biomedicines · 2020Review
- Synanthropic rodents as virus reservoirs and transmitters.Revista da Sociedade Brasileira de Medicina Tropical · 2020Review
- Detection of alpha- and betacoronaviruses in rodents from Yunnan, China.Virology journal · 2017Article
- Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology.The Journal of general virology · 2014Article
- Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses.Virus research · 2013Article
- Article
- Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis.American journal of respiratory cell and molecular biology · 2012Article
- Infection of human alveolar macrophages by human coronavirus strain 229E.The Journal of general virology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The rat coronavirus sialodacryoadenitis virus (SDAV) causes respiratory infection and provides a system for investigating respiratory coronaviruses in a natural host. A viral suspension in the form of a microspray aerosol was delivered by intratracheal instillation into the distal lung of 6-8-week-old Fischer 344 rats. SDAV inoculation produced a 7 % body weight loss over a 5 day period that was followed by recovery over the next 7 days. SDAV caused focal lesions in the lung, which were most severe on day 4 post-inoculation (p.i.). Immunofluorescent staining showed that four cell types supported SDAV virus replication in the lower respiratory tract, namely Clara cells, ciliated cells in the bronchial airway and alveolar type I and type II cells in the lung parenchyma. In bronchial alveolar lavage fluid (BALF) a neutrophil influx increased the population of neutrophils to 45 % compared with 6 % of the cells in control samples on day 2 after mock inoculation. Virus infection induced an increase in surfactant protein SP-D levels in BALF of infected rats on days 4 and 8 p.i. that subsided by day 12. The concentrations of chemokines MCP-1, LIX and CINC-1 in BALF increased on day 4 p.i., but returned to control levels by day 8. Intratracheal instillation of rats with SDAV coronavirus caused an acute, self-limited infection that is a useful model for studying the early events of the innate immune response to respiratory coronavirus infections in lungs of the natural virus host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.