ArticleNucleic acids research2009
Evidence for large diversity in the human transcriptome created by Alu RNA editing.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Spatial transcriptomics reveals laminar and cell-type-specific A-to-I RNA editing signatures in the macaque cortex.Nature communications · 2026Article
- Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases.Molecular therapy. Nucleic acids · 2024Review
- Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus.BMC biology · 2023Article
- A hierarchy in clusters of cephalopod mRNA editing sites.Scientific reports · 2022Article
- Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas.Communications biology · 2022Article
- Article
- Databases for RNA Editing Collections.Methods in molecular biology (Clifton, N.J.) · 2021Article
- RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification.Frontiers in genetics · 2021Article
- Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.Cell reports · 2019Article
- ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.RNA biology · 2017Article
- A-to-I RNA editing promotes developmental stage-specific gene and lncRNA expression.Genome research · 2017Article
- Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.Nature medicine · 2016Article
- Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease.RNA (New York, N.Y.) · 2016Article
- New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins.Biomolecules · 2015Review
- Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method.Nature protocols · 2015Article
- Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript.RNA biology · 2015Article
- ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain.Nucleic acids research · 2014Article
- A genome-wide map of hyper-edited RNA reveals numerous new sites.Nature communications · 2014Article
- A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.Genome research · 2014Article
- Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain.RNA biology · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenosine-to-inosine (A-to-I) RNA editing alters the original genomic content of the human transcriptome and is essential for maintenance of normal life in mammals. A-to-I editing in Alu repeats is abundant in the human genome, with many thousands of expressed Alu sequences undergoing editing. Little is known so far about the contribution of Alu editing to transcriptome complexity. Transcripts derived from a single edited Alu sequence can be edited in multiple sites, and thus could theoretically generate a large number of different transcripts. Here we explored whether the combinatorial potential nature of edited Alu sequences is actually fulfilled in the human transcriptome. We analyzed datasets of editing sites and performed an analysis of a detailed transcript set of one edited Alu sequence. We found that editing appears at many more sites than detected by earlier genomic screens. To a large extent, editing of different sites within the same transcript is only weakly correlated. Thus, rather than finding a few versions of each transcript, a large number of edited variants arise, resulting in immense transcript diversity that eclipses alternative splicing as mechanism of transcriptome diversity, although with less impact on the proteome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.