ArticleThe Journal of biological chemistry2009
Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.Cells · 2021Article
- Alternative splicing landscape of the neural transcriptome in a cytoplasmic-predominant Pten expression murine model of autism-like Behavior.Translational psychiatry · 2020Article
- Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway.Autophagy · 2019Article
- Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines.PloS one · 2017Article
- Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.Oncotarget · 2016Article
- The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells.Scientific reports · 2015Article
- The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.Human molecular genetics · 2015Article
- C-terminally truncated form of αB-crystallin is associated with IDH1 R132H mutation in anaplastic astrocytoma.Journal of neuro-oncology · 2014Article
- Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer.International journal of molecular sciences · 2013Article
- Proteomic identification of mitochondrial targets of arginase in human breast cancer.PloS one · 2013Article
- Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.PloS one · 2013Article
- Novel Cell and Tissue Acquisition System (CTAS): microdissection of live and frozen brain tissues.PloS one · 2012Article
- Determining PTEN functional status by network component deduced transcription factor activities.PloS one · 2012Article
- PTEN level in tumor suppression: how much is too little?Cancer research · 2011Review
- PTEN-Associated Complexes: An Overview.Current topics in biochemical research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is well characterized for its role in antagonizing the phosphoinositide 3-kinase pathway. Previous studies using size-exclusion chromatography demonstrated PTEN recruitment into high molecular mass complexes and hypothesized that PTEN phosphorylation status and PDZ binding domain may be required for such complex formation. In this study, we set out to test the structural requirements for PTEN complex assembly and identify the component(s) of the PTEN complex(es). Our results demonstrated that the PTEN catalytic function and PDZ binding domain are not absolutely required for its complex formation. On the other hand, PTEN phosphorylation status has a significant impact on its complex assembly. Our results further demonstrate enrichment of the PTEN complex in nuclear lysates, suggesting a mechanism through which PTEN phosphorylation may regulate its complex assembly. These results prompted further characterization of other protein components within the PTEN complex(es). Using size-exclusion chromatography and two-dimensional difference gel electrophoresis followed by mass spectrometry analysis, we identified heterogeneous nuclear ribonucleoprotein C (hnRNP C) as a novel protein recruited to higher molecular mass fractions in the presence of PTEN. Further analysis indicates that endogenous hnRNP C and PTEN interact and co-localize within the nucleus, suggesting a potential role for PTEN, alongside hnRNP C, in RNA regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.