Evidence map›Paper›PMID 19740733›Full record

ReviewTopics in stroke rehabilitation

Brain plasticity and genetic factors.

Kristin M Pearson-Fuhrhop, Jeffrey A Kleim, Steven C Cramer

Open access · greenAbstract readReview
In one paragraph

Review in Topics in stroke rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Parkinson's disease, aerobic exercise and photobiomodulation: a randomised controlled trial.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Trial
  3. Trial
  4. Learning as the unifying mechanism of psychedelic action.Journal of psychopharmacology (Oxford, England) · 2026
    Review
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  18. Molecular foundations of chiropractic therapy.Acta bio-medica : Atenei Parmensis · 2019
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kristin M Pearson-FuhrhopDepartment of Anatomy & Neurobiology, University of California, Irvine, Orange, USA.
Jeffrey A Kleim
Steven C Cramer
University of California, Irvine · USUniversity of Florida · US

Funding

BDNF Genotype, Cortical Plasticity and Recovery From StrokeR01NS058755 · NINDS · UNIVERSITY OF FLORIDA · PI KLEIM, JEFFREY A · 2008 to 2011
$1.5M
NINDS NIH HHS R01 NS058755
6 · The paper itself

Abstract

Brain plasticity refers to changes in brain function and structure that arise in a number of contexts. One area in which brain plasticity is of considerable interest is recovery from stroke, both spontaneous and treatment-induced. A number of factors influence these poststroke brain events. The current review considers the impact of genetic factors. Polymorphisms in the human genes coding for brain-derived neurotrophic factor (BDNF) and apolipoprotein E (ApoE) have been studied in the context of plasticity and/or stroke recovery and are discussed here in detail. Several other genetic polymorphisms are indirectly involved in stroke recovery through their modulating influences on processes such as depression and pharmacotherapy effects. Finally, new genetic polymorphisms that have not been studied in the context of stroke are proposed as new directions for study. A better understanding of genetic influences on recovery and response to therapy might allow improved treatment after stroke.

Indexed as

AnimalsHumansNerve Tissue ProteinsNeuronal PlasticityRecovery of FunctionStrokeStroke RehabilitationNerve Tissue Proteins

Identifiers

PMID19740733
PMCPMC5800512
OpenAlexW1980078223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.