ArticleJournal of feline medicine and surgery2010
Prospective evaluation of tissue plasminogen activator in 11 cats with arterial thromboembolism.
Article in Journal of feline medicine and surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Multicentre aortic thromboembolism thrombolysis evaluation in a retrospective study of 183 cats: the MATTERS study.Frontiers in veterinary science · 2026Article
- Treatment and Prevention of Cardiogenic Arterial Thromboembolism in the Cat: A Systematic Review.Animals : an open access journal from MDPI · 2025Review
- Clinical-Diagnostic and Therapeutic Advances in Feline Hypertrophic Cardiomyopathy.Veterinary sciences · 2025Review
- Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.Frontiers in veterinary science · 2025Article
- Surgical treatment and outcomes in feline aortic thromboembolism: a retrospective study of 13 cats.Frontiers in veterinary science · 2025Article
- Feline Aortic Thromboembolism: Recent advances and future prospects.Journal of feline medicine and surgery · 2024Review
- Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism.Journal of feline medicine and surgery · 2022Article
- Retrospective Evaluation of Intravenous Enoxaparin Administration in Feline Arterial Thromboembolism.Animals : an open access journal from MDPI · 2022Article
- 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- The Feline Cardiomyopathies: 1. General concepts.Journal of feline medicine and surgery · 2021Article
- Usefulness of peripheral venous blood gas analyses in cats with arterial thromboembolism.International journal of veterinary science and medicine · 2021Article
- ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats.Journal of veterinary internal medicine · 2020Article
- The Rare Occurrence of a Left Atrial Thrombus in a Dog.Case reports in veterinary medicine · 2020Article
- Thrombolysis with tissue plasminogen activator (TPA) in feline acute aortic thromboembolism: a retrospective study of 16 cases.Journal of feline medicine and surgery · 2019Article
- Arterial thromboembolism: risks, realities and a rational first-line approach.Journal of feline medicine and surgery · 2012Review
- Arterial thromboembolism in 250 cats in general practice: 2004-2012.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the clinical response and side effects of tissue plasminogen activator (tPA) for the treatment of feline arterial thromboembolism (ATE). Previous reports of conservative and thrombolytic therapy were used to provide a historical control group of cats with ATE. The study was terminated due to a high frequency of adverse outcomes. tPA was administered to 11 cats with clinical signs of ATE for a median duration of 4.0 h (range 2-12h) prior to treatment. Pulses were restored in 40% of limbs within 4h and 53% within 24h. Motor function was restored to 33% of limbs within 24h. Adverse effects were seen in 11/11 cats following administration of tPA including azotemia (n=5), neurological signs (n=5), cardiac arrhythmias (n=5), hyperkalemia (n=4), acidosis (n=2) and sudden death in one cat. Ultimately, three cats (27%) were discharged alive from the hospital. While signs compatible with thrombolysis were noted in many cats following tPA administration, a high rate of side effects and low rate of hospital discharge were noted in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.