ArticleImmunology2009
Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.
Article in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preventing surgery-induced natural killer cell suppression and metastases by inhibiting PI3K-gamma signaling in myeloid-derived suppressor cells.Journal for immunotherapy of cancer · 2026Article
- Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.The Journal of clinical investigation · 2021Article
- Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma.Frontiers in oncology · 2021Article
- Review
- Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells.Scientific reports · 2019Article
- TREM-1 promotes intestinal tumorigenesis.Scientific reports · 2017Article
- Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance.Obesity (Silver Spring, Md.) · 2017Article
- TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.Nature communications · 2016Article
- Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils.Scientific reports · 2016Article
- TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Article
- A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages.Immune network · 2015Article
- Differential upregulation of the hypothetical transmembrane protein 66 (Biomedical reports · 2015Article
- TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.PLoS pathogens · 2014Article
- Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis.PloS one · 2014Article
- Colonic epithelial response to injury requires Myd88 signaling in myeloid cells.Mucosal immunology · 2012Article
- Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function.Trends in immunology · 2011Review
- Cervical remodeling during pregnancy and parturition.Trends in endocrinology and metabolism: TEM · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor involved in inflammatory diseases and septic shock. The TREM-1 ligand(s) (TREM-1L) have not yet been identified. In this study, we performed a detailed analysis of the expression of mouse TREM-1 and its ligand(s). Our results demonstrate that TREM-1 is expressed on bone-marrow-derived dendritic cells (BMDC). On bone-marrow-derived macrophages (BMM) its expression is induced in vitro after stimulation by granulocyte-macrophage colony-stimulating factor, interleukin-3 or by myeloid differentiation primary response gene 88 (MyD88)-dependent Toll-like receptor (TLR) ligands. Under steady-state conditions mouse TREM-1 is detectable on a Gr-1(-) F4/80(+) monocyte subpopulation bearing markers of resident monocytes, but not on Gr-1(+) F4/80(+) inflammatory monocytes. During lipopolysaccharide (LPS)-induced endotoxaemia TREM-1 was also up-regulated on inflammatory Gr-1(+) F4/80(+) cells in vivo. In tumour-bearing mice, TREM-1 was up-regulated on Gr-1(+) F4/80(+) monocytes, which phenotypically and functionally resembled mononuclear myeloid-derived suppressor cells. Using a soluble TREM-1 fusion protein, we demonstrate that after intravenous injection of LPS TREM-1L was induced on Gr-1(+) granulocytes and monocytes but not on other cell populations in peripheral blood. This up-regulation on granulocytes was directly mediated by TLR ligands and required the adapter protein MyD88. In contrast to human, mouse platelets expressed TREM-1L neither under steady-state conditions nor after LPS injection in vivo. Our study reveals differential regulation of TREM-1 expression on mouse monocyte subpopulations and improves our understanding of the biological role of TREM-1 during disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.