ArticleImmunology2009
Balance between early life tolerance and sensitization in allergy: dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother.
Article in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Preconceptional Immunization Can Modulate Offspring Intrathymic IL-17-Producing γδT Cells with Epigenetic Implications Mediated by microRNAs.International journal of molecular sciences · 2021Article
- Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.Frontiers in immunology · 2019Review
- Preconception immunization can modulate intracellular Th2 cytokine profile in offspring:Central-European journal of immunology · 2018Article
- Low doses of IgG from atopic individuals can modulate in vitro IFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach.Human vaccines & immunotherapeutics · 2017Article
- Indirect effects of immunological tolerance to a regular dietary protein reduce cutaneous scar formation.Immunology · 2017Article
- Allergen-specific IgG as a mediator of allergy inhibition: Lessons from mother to child.Human vaccines & immunotherapeutics · 2017Review
- Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017Article
- Risk of Allergic Rhinitis, Allergic Conjunctivitis, and Eczema in Children Born to Mothers with Gum Inflammation during Pregnancy.PloS one · 2016Article
- TGF-β-mediated airway tolerance to allergens induced by peptide-based immunomodulatory mucosal vaccination.Mucosal immunology · 2015Article
- Developing Primary Intervention Strategies to Prevent Allergic Disease.Current allergy and asthma reports · 2015Review
- Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?Clinical epigenetics · 2015Article
- Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance.PloS one · 2015Article
- Influence of maternal immunization with allergens on the thymic maturation of lymphocytes with regulatory potential in children: a broad field for further exploration.Journal of immunology research · 2014Review
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- Association between Household Income and Asthma Symptoms among Elementary School Children in Seoul.Environmental health and toxicology · 2012Article
- Maternal LAMP/p55gagHIV-1 DNA immunization induces in utero priming and a long-lasting immune response in vaccinated neonates.PloS one · 2012Article
- Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergens can be maternally transferred to the fetus or neonate, though it is uncertain how this initial allergen exposure may impact the development of allergy responses. To evaluate the roles of timing and level of maternal allergen exposure in the early life sensitization of progeny, female BALB/c mice were given ovalbumin (OVA) orally during pregnancy, lactation or weekly at each stage to investigate the immunoglobulin E (IgE) antibody production and cellular responsiveness of their offspring. Exposure to OVA during pregnancy was also evaluated in OVA-specific T-cell receptor (TCR) transgenic (DO11.10) mice. The effect of prenatal antigen exposure on offspring sensitization was dependent on antigen intake, with low-dose OVA inducing tolerance followed by neonatal immunization that was sustained even when pups were immunized when 3 weeks old. These offspring received high levels of transforming growth factor-beta via breastfeeding. High-dose exposure during the first week of pregnancy or perinatal period induced transient inhibition of IgE production following neonatal immunization; although for later immunization IgE production was enhanced in these offspring. Postnatal maternal antigen exposure provided OVA transference via breastfeeding, which consequently induced increased offspring susceptibility to IgE antibody production according to week post-birth. The effect of low-dose maternal exposure during pregnancy was further evaluated using OVA transgenic TCR dams as a model. These progeny presented pronounced entry of CD4(+) T cells into the S phase of the cell cycle with a skewed T helper type 2 response early in life, revealing the occurrence of allergen priming in utero. The balance between tolerance and sensitization depended on the amount and timing of maternal allergen intake during pregnancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.