ArticleDevelopmental psychobiology2009
Heart rate variability in response to pain stimulus in VLBW infants followed longitudinally during NICU stay.
Article in Developmental psychobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Baseline NIPEEuropean journal of pediatrics · 2025Observational
- Understanding infant stress in neonatal and pediatric intensive care: a scoping review.Intensive care medicine. Paediatric and neonatal · 2025Review
- Heart rate variability and amplitude-integrated electroencephalography measured shortly after birth and time to reach clinical milestones: a pilot study in late preterm infants.Frontiers in pediatrics · 2025Article
- An investigation of cardiac vagal tone over time and its relation to vigilance performance: a growth curve modeling approach.Frontiers in neuroergonomics · 2023Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- The newborn infant parasympathetic evaluation index for acute procedural pain assessment in preterm infants.Pediatric research · 2021Observational
- Cardiac autonomic modulation in response to a glucose stimulus.Medical & biological engineering & computing · 2019Article
- Associations between respiratory arrhythmia and fundamental frequency of spontaneous crying in preterm and term infants at term-equivalent age.Developmental psychobiology · 2016Article
- Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants.Neurogastroenterology and motility · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The objective of this longitudinal study, conducted in a neonatal intensive care unit, was to characterize the response to pain of high-risk very low birth weight infants (<1,500 g) from 23 to 38 weeks post-menstrual age (PMA) by measuring heart rate variability (HRV). Heart period data were recorded before, during, and after a heel lanced or wrist venipunctured blood draw for routine clinical evaluation. Pain response to the blood draw procedure and age-related changes of HRV in low-frequency and high-frequency bands were modeled with linear mixed-effects models. HRV in both bands decreased during pain, followed by a recovery to near-baseline levels. Venipuncture and mechanical ventilation were factors that attenuated the HRV response to pain. HRV at the baseline increased with post-menstrual age but the growth rate of high-frequency power was reduced in mechanically ventilated infants. There was some evidence that low-frequency HRV response to pain improved with advancing PMA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.