ReviewJournal of infection in developing countries2008
Increasing evidence of the role of Helicobacter pylori SabA in the pathogenesis of gastroduodenal disease.
Review in Journal of infection in developing countries, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 86 citations in OpenAlex.
- Prevalence and correlation with clinical diseases of Helicobacter pylori cagA and vacA genotype among gastric patients from Northeast China.BioMed research international · 2014Trial
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- Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025Review
- Saucerneol D Suppresses the Growth ofCurrent issues in molecular biology · 2025Article
- Evaluation of theAnti-cancer agents in medicinal chemistry · 2025Article
- Deoxyshikonin: a promising lead drug grass against drug resistance or sensitivity toAntimicrobial agents and chemotherapy · 2024Article
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- Pivotal role ofFrontiers in medicine · 2024Review
- The immunopathogenesis ofFrontiers in microbiology · 2024Review
- The Role of Adhesion in Helicobacter pylori Persistent Colonization.Current microbiology · 2023Review
- Helicobacter pylori Chronic Infection Selects for Effective Colonizers of Metaplastic Glands.mBio · 2023Article
- Pathogenomics of Helicobacter pylori.Current topics in microbiology and immunology · 2023Review
- Expression Assessment of theInternational journal of molecular and cellular medicine · 2023Article
- Lactate causes downregulation of Helicobacter pylori adhesin genes sabA and labA while dampening the production of proinflammatory cytokines.Scientific reports · 2022Article
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance fromBiomolecules · 2022Review
- Geographic diversity in Helicobacter pylori oipA genotype between Korean and United States isolates.Journal of microbiology (Seoul, Korea) · 2021Article
- Hesperetin Inhibits Expression of Virulence Factors and Growth ofInternational journal of molecular sciences · 2021Article
- Review
- Alterations of Fucosyltransferase Genes and Fucosylated Glycans in Gastric Epithelial Cells Infected withPathogens (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although infection with Helicobacter pylori always results in chronic active gastritis, only a fraction of those infected develop severe clinical disease. In addition, certain populations with high incidences of H. pylori infection, such as those in East Asian countries, have high incidences of gastric cancer, while other highly infected populations, such as those in Africa and South Asia, do not. This phenomenon might be partially explained by differences in the genotypes of H. pylori; however, currently no definite H. pylori factors can clearly explain it. Recently, the importance of sialic acid binding adhesin (SabA), a novel outer membrane protein in gastroduodenal pathogenesis, has become increasingly apparent. Binding of blood group antigen binding adhesin (BabA) to Lewis b antigen and related fucosylated ABO blood group antigens is probably important in the initial stage of infection. However, when host inflammation increases, expression of sialyl-Lewis x increases, and H. pylori is likely to adhere to the gastric mucosa with SabA. Many of the genes encoding outer membrane proteins undergo phase variation such that not all strains will produce functional proteins, and SabA expression is frequently switched "on" or "off", suggesting that SabA expression can rapidly respond to changing conditions in the stomach or in different regions of the stomach. SabA production is indeed reported to be associated with severe intestinal metaplasia, gastric atrophy, and the development of gastric cancer in both developed and developing countries, confirming the importance of investigating SabA in developing countries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.