ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2009
Serum adiponectin as a predictor of childhood non-Hodgkin's lymphoma: a nationwide case-control study.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies.Oncotarget · 2016Pooled it
- Adiponectin is associated with poor prognosis in carcinoma patients: evidence from a meta-analysis.Lipids in health and disease · 2015Pooled it
- AdipoRon promotes angiogenesis in B-cell leukemia by modulating pro-angiogenic factors through AdipoR1.Molecular biology reports · 2025Article
- Obesity and Risk for Lymphoma: Possible Role of Leptin.International journal of molecular sciences · 2022Review
- The Association of Pre-diagnostic Inflammatory Markers and Adipokines and the Risk of Non-Hodgkin Lymphoma Development in Egypt.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- The prognostic value of serum and bronchoalveolar lavage levels of adiponectin in advanced non-small-cell lung cancer.Lung cancer management · 2017Article
- Adipokines and Insulin Resistance in Young Adult Survivors of Childhood Cancer.International journal of endocrinology · 2016Article
- Leptin and its receptor in hematologic malignancies.International journal of clinical and experimental medicine · 2015Review
- Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Adiponectin, driver or passenger on the road to insulin sensitivity?Molecular metabolism · 2013Review
- Non-hodgkin lymphoma and circulating markers of inflammation and adiposity in a nested case-control study: the multiethnic cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Role of adiponectin and its receptors in cancer.Cancer biology & medicine · 2012Article
- The role of adiponectin in cancer: a review of current evidence.Endocrine reviews · 2012Review
- Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia.Pediatric blood & cancer · 2012Article
- Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration.Cell communication and signaling : CCS · 2009Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo our knowledge, this is the first study exploring the association of childhood non-Hodgkin's lymphoma (NHL) with serum adiponectin and leptin levels in a nationwide case-control series. In addition, expression of adiponectin receptors in NHL specimens was assessed, and the association between adipokines and childhood NHL survival and prognosis was examined. PATIENTS AND
methodsWe studied 121 incident childhood (0 to 14 years) NHL cases registered in the Nationwide Registry for Childhood Hematological Malignancies (1996 to 2006) and an equal number of matched controls, for whom sociodemographic, lifestyle, prenatal characteristics, and fasting blood serums were collected. Serum adiponectin and leptin levels were determined. Immunohistochemisty for adiponectin receptors expression was performed on commercially available adult NHL specimens (n = 30) and in a subset of childhood NHL cases (n = 6) that were available. Summary statistics, multiple conditional logistic regression analyses, and survival analysis were performed.
resultsHigher serum adiponectin, but not leptin, levels were independently associated with childhood NHL (odds ratio, 1.82; 95% CI, 1.30 to 2.56), after adjusting for obesity and established risk factors. Higher adiponectin levels at diagnosis were positively associated with relapse and poor survival, but hormone levels did not differ among NHL subtypes. Adiponectin receptors 1 and 2 were present in 90% and 57% of adult samples and in 83% and 100% of childhood NHL samples, respectively.
conclusionElevated serum adiponectin, but not leptin, levels are independently associated with childhood NHL and poor prognosis. Adiponectin receptors are expressed in NHL, suggesting that adiponectin may represent not only a potential clinically significant diagnostic and prognostic marker but also a molecule that may be implicated in NHL pathogenesis.
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