ArticleBlood2009
A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32.Blood · 2012Pooled it
- Article
- Global burden of Hodgkin lymphoma among children and adolescents: a population-based study using GBD 2021.Frontiers in pediatrics · 2025Article
- Exploring the causality of appendectomy and ischaemic heart disease: a Mendelian randomization study and meta-analysis.Frontiers in cardiovascular medicine · 2024Article
- A population-based analysis of hematological malignancies from a French-West-Indies cancer registry's data (2009-2018).BMC cancer · 2023Article
- Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies.International journal of molecular sciences · 2023Review
- Hodgkin Lymphoma: Biology and Differential Diagnostic Problem.Diagnostics (Basel, Switzerland) · 2022Review
- Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking.Cancers · 2021Article
- Insuline-Like Growth Factor-2 (IGF2) and Hepatocyte Growth Factor (HGF) Promote Lymphomagenesis in p53-null Mice in Tissue-specific and Estrogen-signaling Dependent Manners.Journal of Cancer · 2021Article
- Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms.Clinical Medicine Insights. Oncology · 2021Review
- The microbiome in pediatric oncology.Cancer · 2020Review
- Classical Hodgkin's Lymphoma in the Era of Immune Checkpoint Inhibition.Journal of clinical medicine · 2019Review
- DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin.Leukemia & lymphoma · 2019Article
- Childhood use of antimicrobials and risk of Hodgkin lymphoma: a Danish register-based cohort study.Blood advances · 2019Article
- A causal mechanism for childhood acute lymphoblastic leukaemia.Nature reviews. Cancer · 2018Review
- Adolescent reserve capacity, socioeconomic status and school achievement as predictors of mortality in Finland - a longitudinal study.BMC public health · 2017Article
- Allergic conditions are not associated with the risk of non-Hodgkin's lymphoma or Hodgkin's lymphoma: a systematic review and meta-analysis.OncoTargets and therapy · 2017Article
- Relevance of the Measles Virus Expression in Cancer - an Update.Pathology oncology research : POR · 2016Review
- Autoimmune and Atopic Disorders and Risk of Classical Hodgkin Lymphoma.American journal of epidemiology · 2015Article
- Common immune-related exposures/conditions and risk of non-Hodgkin lymphoma: a case-control study of disease-discordant twin pairs.American journal of epidemiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The pattern of adolescent/young adult Hodgkin lymphoma (YAHL) suggests causation by a relatively late infection with a common childhood virus, but no causal virus has been found. Susceptibility is heritable and linked to lower interleukin 12 (IL12) levels, which can also result from fewer fecal-oral microbial exposures early in life. We studied twin pairs discordant for YAHL to examine exposures capable of altering the IL12 response and T-helper type 1 (Th1)-Th2 balance. One hundred eighty-eight YAHL-discordant twin pairs from the International Twin Study returned questionnaires (70% response). Exposure history of YAHL case-twins was compared with that of their unaffected control-twins using conditional logistic regression for matched pairs to calculate odds ratios (ORs). Behaviors likely to produce oral exposure to microbes conveyed decreases in risk (univariable OR range = 0.2-0.5, P = .003-.11). Significant adjusted ORs were seen for appendectomy (OR = 4.3, P = .001), eczema (OR = 4.2, P = .025), smoking (OR = 2.2, P = .054), and relatively more frequent behaviors associated with oral exposures (OR = 0.1; P = .004). Kappa statistics for intrapair agreement were higher than 0.8 for each significant finding. Our observations support a protective role for increased early oral exposure to the microbiome, suggesting that factors associated with increased Th2 and decreased Th1 cytokines are etiologically relevant to YAHL.
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