ArticleAntimicrobial agents and chemotherapy2009
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Ribosome-Directed Therapies in Cancer.Biomedicines · 2022Review
- Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective.Cancers · 2021Review
- A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis.Biochemistry. Biokhimiia · 2020Review
- Review
- Diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, kills various human cancer cells.PloS one · 2019Article
- Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.Annual review of biochemistry · 2018Review
- Review
- First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case.Marine drugs · 2018Article
- Crystal structure of eukaryotic ribosome and its complexes with inhibitors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".Marine drugs · 2016Review
- Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1.The Journal of antibiotics · 2015Article
- The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis.RNA biology · 2015Article
- Article
- Ribosome-targeting antibiotics and mechanisms of bacterial resistance.Nature reviews. Microbiology · 2014Review
- Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nucleic acid helix structure determination from NMR proton chemical shifts.Journal of biomolecular NMR · 2013Article
- Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.Journal of the American Chemical Society · 2012Article
- Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.RNA (New York, N.Y.) · 2011Article
- Antiviral lead compounds from marine sponges.Marine drugs · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.