ArticleInfection and immunity2009
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Evaluation of Four Adjuvant Combinations, IVAX-1, IVAX-2, CpG-1826+Montanide ISA 720 VG and CpG-1018+Montanide ISA 720 VG, for Safety and for Their Ability to Elicit Protective Immune Responses in Mice against a Respiratory Challenge withPathogens (Basel, Switzerland) · 2023Article
- Mast cells selectively produce inflammatory mediators and impact the early response toFrontiers in immunology · 2023Article
- Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas.Scientific reports · 2020Article
- Th17 and Cognitive Impairment: Possible Mechanisms of Action.Frontiers in neuroanatomy · 2019Review
- Enterovirus D68 infection induces IL-17-dependent neutrophilic airway inflammation and hyperresponsiveness.JCI insight · 2018Article
- IL-9 Deficiency Promotes Pulmonary Th17 Response in Murine Model ofFrontiers in immunology · 2018Article
- Knockout of interleukin-17A protects against sepsis-associated acute kidney injury.Annals of intensive care · 2016Article
- A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection.Applied microbiology and biotechnology · 2016Article
- Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.Journal of cellular and molecular medicine · 2016Article
- X-ray Irradiated Vaccine Confers protection against Pneumonia caused by Pseudomonas aeruginosa.Scientific reports · 2016Article
- Article
- Biomarkers in the Management of Difficult Asthma.Current topics in medicinal chemistry · 2016Review
- Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.Infection and immunity · 2015Article
- Mechanisms of Cholera Toxin in the Modulation of TH17 Responses.Critical reviews in immunology · 2015Review
- CD43-, but not CD43+, IL-10-producing CD1dhiCD5+ B cells suppress type 1 immune responses during Chlamydia muridarum genital tract infection.Mucosal immunology · 2015Article
- Downregulation of chicken interleukin-17 receptor A during Eimeria infection.Infection and immunity · 2014Article
- IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.The Journal of investigative dermatology · 2014Article
- Clinical consequences of targeting IL-17 and TH17 in autoimmune and allergic disorders.Current allergy and asthma reports · 2013Review
- Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences.Fibrogenesis & tissue repair · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The specific contribution of interleukin-17/interleukin-17 receptor (IL-17/IL-17R)-mediated responses in regulating host susceptibility against obligatory intracellular Chlamydia infection was investigated in C57BL/6 and C3H/HeN mice during Chlamydia muridarum respiratory infection. We demonstrated that Chlamydia stimulated IL-17/IL-17R-associated responses in both Chlamydia-resistant C57BL/6 and Chlamydia-susceptible C3H/HeN mice. However, C3H/HeN mice developed a significantly greater IL-17/IL-17R-associated response than C57BL/6 mice did. This was reflected by an increase in IL-17 mRNA expression, a higher recall IL-17 production from splenocytes upon antigen restimulation, and higher production of Th17-related cytokines (IL-23 and IL-6) and chemokines (chemokine [C-X-C motif] ligand 2 [CXCL1]/keratinocyte-derived chemokine [KC] and CXCL2/macrophage inflammatory protein 1 [MIP2]) in C3H/HeN mice than in C57BL/6 mice. Furthermore, C3H/HeN mice displayed a massive accumulation of activated and preactivated neutrophils in the airway and lung parenchyma compared to their C57BL/6 counterparts. We further demonstrated that the skewed IL-17/Th17 profile in C3H/HeN mice was predisposed by a higher basal level of IL-17 receptor C (IL-17RC) expression and then further amplified by a higher inducible IL-17RA expression in lungs. Most importantly, in vivo delivery of IL-17RA antagonist that resulted in a 50% reduction in the neutrophilic infiltration in lungs was able to reverse the susceptible phenotype of C3H/HeN mice to respiratory Chlamydia infection. Thus, our data for the first time have demonstrated a critical role for the IL-17/IL-17R axis in regulating host susceptibility to Chlamydia infection in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.