ArticleGenome research2009
Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
- Genomic and epigenomic maps of mouse centromeres and pericentromeres.Nature communications · 2025Article
- Dynamic evolution of satellite DNAs drastically differentiates the genomes ofGenome research · 2025Article
- UniAligner: a parameter-free framework for fast sequence alignment.Nature methods · 2023Article
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- Tandem Repeat Diversity in Two Closely Related Hamster Species-The Chinese Hamster (Biomedicines · 2022Article
- Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice.Scientific reports · 2021Article
- Copy number evolution in simple and complex tandem repeats across the C57BL/6 and C57BL/10 inbred mouse lines.G3 (Bethesda, Md.) · 2021Article
- Improved contiguity of the threespine stickleback genome using long-read sequencing.G3 (Bethesda, Md.) · 2021Article
- Comparison of Karyotypes in Two Hybridizing Passerine Species: Conserved Chromosomal Structure but Divergence in Centromeric Repeats.Frontiers in genetics · 2021Article
- Assembly of the threespine stickleback Y chromosome reveals convergent signatures of sex chromosome evolution.Genome biology · 2020Article
- Satellite DNAs are conserved and differentially transcribed among Gryllus cricket species.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Review
- Regular Higher Order Repeat Structures in Beetle Tribolium castaneum Genome.Genome biology and evolution · 2017Article
- Large deletion on the Y-chromosome long arm (Yq) of C57BL/6JBomTac inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Centromere inactivation on a neo-Y fusion chromosome in threespine stickleback fish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus.BMC genomics · 2016Article
- LINE-related component of mouse heterochromatin and complex chromocenters' composition.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Repression of harmful meiotic recombination in centromeric regions.Seminars in cell & developmental biology · 2016Review
- Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Y centromere sequence of house mouse, Mus musculus, remains unknown despite our otherwise significant knowledge of the genome sequence of this important mammalian model organism. Here, we report the complete molecular characterization of the C57BL/6J chromosome Y centromere, which comprises a highly diverged minor satellite-like sequence (designated Ymin) with higher-order repeat (HOR) sequence organization previously undescribed at mouse centromeres. The Ymin array is approximately 90 kb in length and resides within a single BAC clone that provides sequence information spanning an endogenous animal centromere for the first time. By exploiting direct patrilineal inheritance of the Y chromosome, we demonstrate stability of the Y centromere DNA structure spanning at least 175 inbred generations to beyond the time of domestication of the East Asian M.m. molossinus "fancy" mouse through which the Y chromosome was first introduced into the classical inbred laboratory mouse strains. Despite this stability, at least three unequal genetic exchange events have altered Ymin HOR unit length and sequence structure since divergence of the ancestral Mus musculus subspecies around 900,000 yr ago, with major turnover of the HOR arrays driving rapid divergence of sequence and higher-order structure at the mouse Y centromere. A comparative sequence analysis between the human and chimpanzee centromeres indicates a similar rapid divergence of the primate Y centromere. Our data point to a unique DNA sequence and organizational architecture for the mouse Y centromere that has evolved independently of all other mouse centromeres.
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