ArticleGenetics2009
Identification of a Cis-acting regulatory polymorphism in a Eucalypt COBRA-like gene affecting cellulose content.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- Uncovering epigenetic and transcriptional regulation of growth in Douglas-fir: identification of differential methylation regions in mega-sized introns.Plant biotechnology journal · 2024Article
- CAGEs are Golgi-localized GT31 enzymes involved in cellulose biosynthesis in Arabidopsis.The Plant journal : for cell and molecular biology · 2022Article
- Identification of Candidate Gene-Based Markers for Girth Growth in Rubber Trees.Plants (Basel, Switzerland) · 2021Article
- First record of off-season flowering in Populus deltoides from India: paradigm of climate change indicator.International journal of biometeorology · 2020Article
- A Role for Epigenetic Regulation in the Adaptation and Stress Responses of Non-model Plants.Frontiers in plant science · 2019Review
- Thirteen years under arid conditions: exploring marker-trait associations inBreeding science · 2018Article
- Genome-Wide Association Studies to Improve Wood Properties: Challenges and Prospects.Frontiers in plant science · 2018Review
- Increased fire frequency promotes stronger spatial genetic structure and natural selection at regional and local scales in Pinus halepensis Mill.Annals of botany · 2017Article
- Uncovering SNP and indel variations of tetraploid cottons by SLAF-seq.BMC genomics · 2017Article
- Allelic variation in PtoPsbW associated with photosynthesis, growth, and wood properties in Populus tomentosa.Molecular genetics and genomics : MGG · 2017Article
- MLPA-Based Analysis of Copy Number Variation in Plant Populations.Frontiers in plant science · 2017Article
- Dissection of Insertion-Deletion Variants within Differentially Expressed Genes Involved in Wood Formation inFrontiers in plant science · 2017Article
- Genetic architecture of wood properties based on association analysis and co-expression networks in white spruce.The New phytologist · 2016Article
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- Single-nucleotide polymorphisms in PtoCesA7 and their association with growth and wood properties in Populus tomentosa.Molecular genetics and genomics : MGG · 2014Article
- RNA-Seq using two populations reveals genes and alleles controlling wood traits and growth in Eucalyptus nitens.PloS one · 2014Article
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- Allelic variation in a cellulose synthase gene (PtoCesA4) associated with growth and wood properties in Populus tomentosa.G3 (Bethesda, Md.) · 2013Article
- Epigenetic regulation of adaptive responses of forest tree species to the environment.Ecology and evolution · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Populations with low linkage disequilibrium (LD) offer unique opportunities to study functional variants influencing quantitative traits. We exploited the low LD in forest trees to identify functional polymorphisms in a Eucalyptus nitens COBRA-like gene (EniCOBL4A), whose Arabidopsis homolog has been implicated in cellulose deposition. Linkage analysis in a full-sib family revealed that EniCOBL4A is the most strongly associated marker in a quantitative trait locus (QTL) region for cellulose content. Analysis of LD by genotyping 11 common single-nucleotide polymorphisms (SNPs) and a simple sequence repeat (SSR) in an association population revealed that LD declines within the length of the gene. Using association studies we fine mapped the effect of the gene to SNP7, a synonymous SNP in exon 5, which occurs between two small haplotype blocks. We observed patterns of allelic expression imbalance (AEI) and differential binding of nuclear proteins to the SNP7 region that indicate that SNP7 is a cis-acting regulatory polymorphism affecting allelic expression. We also observed AEI in SNP7 heterozygotes in a full-sib family that is linked to heritable allele-specific methylation near SNP7. This study demonstrates the potential to reveal functional polymorphisms underlying quantitative traits in low LD populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.