ArticleGenetics2009
Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Adaptive Evolution of Two Distinct Adaptive Haplotypes of Neanderthal Origin at the Immunoglobulin Heavy-chain Locus in East Asian and European Populations.Molecular biology and evolution · 2024Article
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- Understanding signatures of positive natural selection in human zinc transporter genes.Scientific reports · 2022Article
- Article
- Surveillance of Aedes aegypti populations in the city of Praia, Cape Verde: Zika virus infection, insecticide resistance and genetic diversity.Parasites & vectors · 2020Article
- HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases.Frontiers in physiology · 2019Review
- Sequence diversity of the Rh blood group system in Basques.European journal of human genetics : EJHG · 2018Article
- Analysis of population-specific pharmacogenomic variants using next-generation sequencing data.Scientific reports · 2017Article
- Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.BMC medical genetics · 2016Article
- Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations.Genes & nutrition · 2016Article
- Article
- Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.PLoS neglected tropical diseases · 2015Article
- Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.Genome biology · 2014Article
- Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.Nature genetics · 2014Article
- Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.PLoS genetics · 2014Article
- Integrative annotation of variants from 1092 humans: application to cancer genomics.Science (New York, N.Y.) · 2013Article
- The adaptive variant EDARV370A is associated with straight hair in East Asians.Human genetics · 2013Article
- A general linear model-based approach for inferring selection to climate.BMC genetics · 2013Article
- Consequences of a poecilogonous life history for genetic structure in coastal populations of the polychaete Streblospio benedicti.Molecular ecology · 2012Article
- 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care.Human genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
We have evaluated the extent to which SNPs identified by genomewide surveys as showing unusually high levels of population differentiation in humans have experienced recent positive selection, starting from a set of 32 nonsynonymous SNPs in 27 genes highlighted by the HapMap1 project. These SNPs were genotyped again in the HapMap samples and in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel of 52 populations representing worldwide diversity; extended haplotype homozygosity was investigated around all of them, and full resequence data were examined for 9 genes (5 from public sources and 4 from new data sets). For 7 of the genes, genotyping errors were responsible for an artifactual signal of high population differentiation and for 2, the population differentiation did not exceed our significance threshold. For the 18 genes with confirmed high population differentiation, 3 showed evidence of positive selection as measured by unusually extended haplotypes within a population, and 7 more did in between-population analyses. The 9 genes with resequence data included 7 with high population differentiation, and 5 showed evidence of positive selection on the haplotype carrying the nonsynonymous SNP from skewed allele frequency spectra; in addition, 2 showed evidence of positive selection on unrelated haplotypes. Thus, in humans, high population differentiation is (apart from technical artifacts) an effective way of enriching for recently selected genes, but is not an infallible pointer to recent positive selection supported by other lines of evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.