ArticleGenetics2010
Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide association mapping.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed.
- Trans-regulatory loci shape natural variation of gene expression plasticity in Arabidopsis.Genetics · 2025Article
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- Application of GWAS and mGWAS in Livestock and Poultry Breeding.Animals : an open access journal from MDPI · 2024Review
- Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics.Heredity · 2024Article
- Current status of community resources and priorities for weed genomics research.Genome biology · 2024Review
- Complementing model species with model clades.The Plant cell · 2024Review
- Construction of a high-density genetic map based on large-scale marker development in Coix lacryma-jobi L. using specific-locus amplified fragment sequencing (slaf-seq).Scientific reports · 2024Article
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- Traits linked to natural variation of sulfur content in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- QT-GWAS: A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits.Molecular plant · 2023Article
- Assessment of Indian wheat germplasm for Septoria nodorum blotch and tan spot reveals new QTLs conferring resistance along with recessive alleles ofFrontiers in plant science · 2023Article
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- Genome-wide association mapping of septoria nodorum blotch resistance in Nordic winter and spring wheat collections.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Genome-wide association studies: assessing trait characteristics in model and crop plants.Cellular and molecular life sciences : CMLS · 2021Review
- Retrograde sulfur flow from glucosinolates to cysteine inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the improvement and decline in cost of high-throughput genotyping and phenotyping technologies, genome-wide association (GWA) studies are fast becoming a preferred approach for dissecting complex quantitative traits. Glucosinolate (GSL) secondary metabolites within Arabidopsis spp. can serve as a model system to understand the genomic architecture of quantitative traits. GSLs are key defenses against insects in the wild and the relatively large number of cloned quantitative trait locus (QTL) controlling GSL traits allows comparison of GWA to previous QTL analyses. To better understand the specieswide genomic architecture controlling plant-insect interactions and the relative strengths of GWA and QTL studies, we conducted a GWA mapping study using 96 A. thaliana accessions, 43 GSL phenotypes, and approximately 230,000 SNPs. Our GWA analysis identified the two major polymorphic loci controlling GSL variation (AOP and MAM) in natural populations within large blocks of positive associations encompassing dozens of genes. These blocks of positive associations showed extended linkage disequilibrium (LD) that we hypothesize to have arisen from balancing or fluctuating selective sweeps at both the AOP and MAM loci. These potential sweep blocks are likely linked with the formation of new defensive chemistries that alter plant fitness in natural environments. Interestingly, this GWA analysis did not identify the majority of previously identified QTL even though these polymorphisms were present in the GWA population. This may be partly explained by a nonrandom distribution of phenotypic variation across population subgroups that links population structure and GSL variation, suggesting that natural selection can hinder the detection of phenotype-genotype associations in natural populations.
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