ArticleGenetics2009
Epithelial polarity: interactions between junctions and apical-basal machinery.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells.Development (Cambridge, England) · 2024Article
- Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity.Cell adhesion & migration · 2023Article
- Scribble basal polarity acquisition in RPE cells and its mislocalization in a pathological AMD-like model.Frontiers in neuroanatomy · 2022Article
- WNT Signaling in Disease.Cells · 2019Review
- Article
- Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis.Scientific reports · 2017Article
- An embryonic system to assess direct and indirect Wnt transcriptional targets.Scientific reports · 2017Article
- A Kinome RNAi Screen inG3 (Bethesda, Md.) · 2017Article
- Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.Scientific reports · 2017Article
- Review
- Article
- Review
- Article
- Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.Genetics · 2014Article
- Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.Developmental biology · 2013Article
- Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle.Development (Cambridge, England) · 2013Article
- PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.The EMBO journal · 2011Article
- Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.PloS one · 2011Article
- Epicardial spindle orientation controls cell entry into the myocardium.Developmental cell · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial polarity is established and maintained by competition between determinants that define the apical and basolateral domains. Cell-cell adhesion complexes, or adherens junctions, form at the interface of these regions. Mutations in adhesion components as well as apical determinants normally lead to an expansion of the basolateral domain. Here we investigate the genetic relationship between the polarity determinants and adhesion and show that the levels of the adhesion protein Armadillo affect competition. We find that in arm mutants, even a modest reduction in the basolateral component lgl leads to a full apical domain expansion or lgl phenotype. By using an allelic series of Armadillo mutations, we show that there is a threshold at which basolateral expansion can be reversed. Further, in embryos lacking the Wingless signaling component zw3, the same full apical expansion occurs again with only a reduction in lgl. We propose a model where zw3 regulates protein levels of apical and adhesion components and suggest that a reciprocal interaction between junctions and polarity modules functions to maintain stable apical and basolateral domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.