ArticleJournal of experimental & clinical cancer research : CR2009
Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.
Article in Journal of experimental & clinical cancer research : CR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer.Cancer biomarkers : section A of Disease markers · 2023Article
- Kuoxin Decoction promotes lymphangiogenesis in zebrafish andFrontiers in pharmacology · 2022Article
- Long non-coding RNAs involved in metastasis of gastric cancer.World journal of gastroenterology · 2018Review
- The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.International journal of molecular sciences · 2017Review
- Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications.World journal of gastroenterology · 2016Review
- Long non-coding RNAs: emerging players in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- The non-coding transcriptome as a dynamic regulator of cancer metastasis.Cancer metastasis reviews · 2014Review
- Long non-coding RNA expression profile in human gastric cancer and its clinical significances.Journal of translational medicine · 2013Article
- Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer.American journal of stem cells · 2012Article
- Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis.Journal of experimental & clinical cancer research : CR · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the clinicopathological features of gastric cancers with loss of imprinting (LOI) of LIT1. Insulin-like growth factor 2 (IGF2) and H19 in Chinese patients.
methodsDNA and RNA from tumours were amplified and then digested with RsaI, ApaI and HinfI, and RsaI respectively to determine the LOI status. The demographic and clinicopathological characteristics in LOI positive and LOI negative patients were compared and tested with Statistical analysis.
resultsOf the 89 patients enrolled for analysis, 22, 40 and 35 were heterozygous and thus informative for LIT1, IGF2 and H19 LOI analyses respectively. The positive rate of LIT1, IGF2 and H19 LOI of gastric cancer tissues were 54.6% (12/22), 45% (18/40) and 8.6% (3/32) in Chinese patients. Gastric corpus cancer (8/10, 80%) were more likely to have LOI of IGF2 in tumours than antrum cancers (10/30, 33.3%){odds ratio (OR) = 8, 95% confidence intervals (CI) = 1.425-44.920, p = 0.018)}. LOI of IGF2 in tumours was also associated with the lymph node metastasis (LNM) (OR = 4.5, 95% CI = 1.084-18.689, p = 0.038).
conclusionIGF2 LOI is present in high frequency in Chinese gastric cancer patients, especially those with gastric corpus cancer.
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