ArticleBMC microbiology2009
Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori.Communications biology · 2023Article
- Epigenetics andInternational journal of molecular sciences · 2022Review
- Methylation Motifs in Promoter Sequences May Contribute to the Maintenance of a ConservedMicroorganisms · 2021Article
- Protein-Coding Genes ofGenes · 2021Article
- Identification of NewFrontiers in microbiology · 2020Article
- Networking and Specificity-Changing DNA Methyltransferases inFrontiers in microbiology · 2020Article
- Analysis of genetic recombination and the pan-genome of a highly recombinogenic bacteriophage species.Microbial genomics · 2019Article
- The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori.Nucleic acids research · 2019Article
- The complete genome and methylome ofGut pathogens · 2019Article
- Relating Phage Genomes toInternational journal of molecular sciences · 2018Review
- The complete methylome of Helicobacter pylori UM032.BMC genomics · 2015Article
- Article
- Helicobacter pylori infection - recent developments in diagnosis.World journal of gastroenterology · 2014Review
- Methylome diversification through changes in DNA methyltransferase sequence specificity.PLoS genetics · 2014Article
- The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts.Nucleic acids research · 2014Article
- Mobility of DNA sequence recognition domains in DNA methyltransferases suggests epigenetics-driven adaptive evolution.Mobile genetic elements · 2012Article
- Article
- Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in theGut microbesArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases.
resultsIndependence tests and logistic regression models revealed that ten R-M systems correlate with geographical localization. The distribution pattern of these methyltransferases may have been originated by co-divergence of regional H. pylori after its human host migrated out of Africa. The expression of specific methyltransferases in the H. pylori population may also reflect the genetic and cultural background of its human host. Methyltransferases common to all strains, M. HhaI and M. NaeI, are likely conserved in H. pylori, and may have been present in the bacteria genome since the human diaspora out of Africa.
conclusionThis study indicates that some methyltransferases are useful geomarkers, which allow discrimination of bacterial populations, and that can be added to our tools to investigate human migrations.
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