ArticleBMC cancer2009
Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Prostate cancer research: tools, cell types, and molecular targets.Frontiers in oncology · 2024Review
- The opposing action of stromal cell proenkephalin and stem cell transcription factors in prostate cancer differentiation.BMC cancer · 2021Article
- Identification and validation of a six immune-related gene signature for prediction of biochemical recurrence in localized prostate cancer following radical prostatectomy.Translational andrology and urology · 2021Article
- Selection and Evaluation of Specific Single Chain Antibodies against CD90, a Marker for Mesenchymal and Cancer Stem Cells.Reports of biochemistry & molecular biology · 2018Article
- Multiplexed targeted mass spectrometry assays for prostate cancer-associated urinary proteins.Oncotarget · 2017Article
- Asporin is a stromally expressed marker associated with prostate cancer progression.British journal of cancer · 2017Article
- Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.Scientific reports · 2017Article
- Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse.Frontiers in neuroscience · 2017Article
- An efficient method for native protein purification in the selected range from prostate cancer tissue digests.Chinese clinical oncology · 2016Article
- Overexpression of Thy1 and ITGA6 is associated with invasion, metastasis and poor prognosis in human gallbladder carcinoma.Oncology letters · 2016Article
- Multiple roles of CD90 in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Cancer-secreted AGR2 induces programmed cell death in normal cells.Oncotarget · 2016Article
- Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors.Oncogenesis · 2015Article
- Reprogramming of prostate cancer cells--technical challenges.Current urology reports · 2015Review
- Similarity of markers identified from cancer gene expression studies: observations from GEO.Briefings in bioinformatics · 2014Article
- Gene Expression Profiling Reveals Regulation of ERK Phosphorylation by Androgen-Induced Tumor Suppressor U19/EAF2 in the Mouse Prostate.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- Semantic integration of gene expression analysis tools and data sources using software connectors.BMC genomics · 2013Article
- Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression.The Journal of pathology · 2013Article
- The expression of CD90/Thy-1 in hepatocellular carcinoma: an in vivo and in vitro study.PloS one · 2013Article
- Bladder expression of CD cell surface antigens and cell-type-specific transcriptomes.Cell and tissue research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. The tumor-associated stroma is marked by increased expression of CD90/THY1. Isolation and characterization of these stromal cells could provide valuable insight into the biology of the tumor microenvironment.
methodsProstate CD90+ stromal fibromuscular cells from tumor specimens were isolated by cell-sorting and analyzed by DNA microarray. Dataset analysis was used to compare gene expression between histologically normal and tumor-associated stromal cells. For comparison, stromal cells were also isolated and analyzed from the urinary bladder.
resultsThe tumor-associated stromal cells were found to have decreased expression of genes involved in smooth muscle differentiation, and those detected in prostate but not bladder. Other differential expression between the stromal cell types included that of the CXC-chemokine genes.
conclusionCD90+ prostate tumor-associated stromal cells differed from their normal counterpart in expression of multiple genes, some of which are potentially involved in organ development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.