ReviewClinical and experimental immunology2009
Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis.
Review in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 86 citations in OpenAlex.
- Efficacy ofInternational archives of otorhinolaryngology · 2026Article
- Evaluating efficacy and safety of auricular acupressure in treating allergic rhinitis: A randomized controlled trial.Integrative medicine research · 2025Article
- Risk of Permanent Dysfunction of Facial Nerves After Open Rigid Internal Fixation in the Treatment of Mandibular Condylar Process Fracture.Medical sciences (Basel, Switzerland) · 2025Article
- Efficacy and Safety ofAdvances in respiratory medicine · 2025Review
- Review
- Confronting allergies: strategies for combating pollution and safeguarding our health.Frontiers in allergy · 2024Review
- A Review on Novel Therapeutic Modalities and Evidence-based Drug Treatments against Allergic Rhinitis.Current pharmaceutical design · 2024Review
- Common Allergens and Immune Responses Associated with Allergic Rhinitis in China.Journal of asthma and allergy · 2023Review
- The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment.International journal of molecular sciences · 2022Article
- Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients.PeerJ · 2022Article
- Article
- Treatment of Early Allergic and Late Inflammatory Symptoms of Allergic Rhinitis withPharmaceuticals (Basel, Switzerland) · 2021Article
- The Nose as a Route for Therapy: Part 1. Pharmacotherapy.Frontiers in allergy · 2021Review
- A Study on Role of NOSE Scale in the Management of Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2020Article
- Dexamethasone-Induced Perturbations in Tissue Metabolomics Revealed by Chemical Isotope Labeling LC-MS analysis.Metabolites · 2020Article
- Reduction of Allergic Lung Disease by Mucosal Application ofFrontiers in immunology · 2020Article
- Phosphodiesterase 4 Inhibitors in Allergic Rhinitis/Rhinosinusitis.Frontiers in pharmacology · 2020Review
- Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents.Frontiers in pharmacology · 2019Review
- Allergic rhinitis and associated comorbidities: prevalence in oman with knowledge gaps in literature.Oman medical journal · 2014Article
- Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis.Allergy & rhinology (Providence, R.I.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic rhinitis is a common airway disease characterized by hypersensitivity, exudation, hypersecretion, inflammatory cell infiltration and remodelling. Intranasal glucocorticosteroids are the most effective drugs for controlling the inflammation caused by allergic rhinitis. Glucocorticosteroids exert anti-inflammatory effects through at least two pathways: the transactivation pathway and the transrepression pathway. Glucocorticosteroids also exert regulatory functions by inducing regulatory cytokines and forkhead box P3 (FoxP3(+)) regulatory T cells. Evidence suggests that intranasal glucocorticosteroids control not only nasal symptoms but also ocular symptoms. In contrast to sedating H1 receptor antagonists, intranasal glucocorticosteroids can improve impaired performance symptoms, such as daytime sleepiness, associated with allergic rhinitis. Recent studies suggest that intranasal glucocorticosteroids might also be useful for the prophylactic treatment of pollinosis; this possibility is supported by the molecular mechanism of the anti-inflammatory action of glucocorticosteroids. These findings suggest that intranasal glucocorticosteroids might be positioned as first-line drugs for the treatment of both perennial and seasonal allergic rhinitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.