Evidence map›Paper›PMID 19737106›Full record

ReviewAnnual review of pathology2010

The pathobiology of glioma tumors.

Candece L Gladson, Richard A Prayson, Wei Michael Liu

Abstract readReview
In one paragraph

Review in Annual review of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Selective targeting of glioma via the SCARB2 receptor: transcriptomic, proteomic andFrontiers in cellular and infection microbiology · 2025
    Pooled it
  2. Pooled it
  3. Quantitative assessment of the association between XRCC3 C18607T polymorphism and glioma risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  4. Pooled it
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  15. Understanding treatment preferences and cognitive outcomes in patients with gliomas.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  16. Review
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  19. Article
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Candece L GladsonDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA. gladsoc@ccf.org
Richard A Prayson
Wei Michael Liu

Funding

Brain Endothelial TNF-R1 Can Function to Inhibit AngiogenesisR01CA152883 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2010 to 2014
$1.6M
Inhibition of Glioma Growth by a Novel MoleculeR01CA127620 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GLADSON, CANDECE L · 2007 to 2011
$1.4M
The Role of Lyn in Glioma Progression and MigrationR01CA109748 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GLADSON, CANDECE L · 2005 to 2009
$1.4M
NCI NIH HHS CA109748NCI NIH HHS CA127620NCI NIH HHS R01 CA109748NCI NIH HHS R01 CA127620NCI NIH HHS R01 CA152883
6 · The paper itself

Abstract

The ongoing characterization of the genetic and epigenetic alterations in the gliomas has already improved the classification of these heterogeneous tumors and enabled the development of rodent models for analysis of the molecular pathways underlying their proliferative and invasive behavior. Effective application of the targeted therapies that are now in development will depend on pathologists' ability to provide accurate information regarding the genetic alterations and the expression of key receptors and ligands in the tumors. Here we review the mechanisms that have been implicated in the pathogenesis of the gliomas and provide examples of the cooperative nature of the pathways involved, which may influence the initial therapeutic response and the potential for development of resistance.

Indexed as

AnimalsCell ProliferationDisease Models, AnimalEpigenesis, GeneticGliomaHumansSignal Transduction

Identifiers

PMID19737106
PMCPMC2887670

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.