Evidence map›Paper›PMID 19737088›Full record

ReviewAntioxidants & redox signaling2010

Redox control of vascular smooth muscle migration.

Alejandra San Martín, Kathy K Griendling

Abstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Review
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  18. Review
  19. Redox control of vascular smooth muscle cell function and plasticity.Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alejandra San MartínEmory University, Atlanta, Georgia 30087, USA.
Kathy K Griendling
Emory University · US

Funding

Vascular Oxidases in MigrationR01HL058863 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 1997 to 2014
$4.1M
NOX4 and vascular smooth muscle differentiationR37HL038206 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 2006 to 2015
$3.8M
VASCULAR SMOOTH MUSCLE PHOSPHOLIPASE DR01HL038206 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 1993 to 2005
$2.1M
Mechanism of SSH1L Phosphatase Activation in VSMC: Role in Vascular PathologyR00HL093115 · NHLBI · EMORY UNIVERSITY · PI SAN MARTIN, ALEJANDRA · 2009 to 2011
$747k
Mechanism of SSH1L Phosphatase Activation in VSMC: Role in Vascular PathologyK99HL093115 · NHLBI · EMORY UNIVERSITY · PI SAN MARTIN, ALEJANDRA · 2008 to 2008
$81k
DIACYLGLYCEROL SIGNALING IN VASCULAR SMOOTH MUSCLER29HL038206 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 1987 to 1991
–
NHLBI NIH HHS HL058863NHLBI NIH HHS HL093115NHLBI NIH HHS HL38206NHLBI NIH HHS K99 HL093115NHLBI NIH HHS R00 HL093115NHLBI NIH HHS R01 HL058863NHLBI NIH HHS R37 HL038206
6 · The paper itself

Abstract

Vascular smooth muscle cell migration is important during vascular development and contributes to lesion formation in the adult vasculature. The mechanisms regulating migration of this cell type are therefore of great interest. Recent work has shown that reactive oxygen species (ROS) derived from NADPH oxidases are important mediators of promigratory signaling pathways. ROS regulate the intracellular signals responsible for lamellipodia formation, actin cytoskeleton remodeling, focal adhesion turnover, and contraction of the cell body. In addition, they contribute to matrix remodeling, a critical step to initiate and support vascular smooth muscle cell motility. Despite these recent advances in our understanding of the redox mechanisms that contribute to migration, additional work is needed to evaluate fully the potential of ROS-sensitive molecular signals as therapeutic targets to prevent inappropriate smooth muscle cell migration.

Indexed as

ActinsCell MovementCytoskeletonExtracellular MatrixFocal AdhesionsHumansMicrotubulesModels, MolecularMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesOxidation-ReductionProtein ConformationPseudopodiaReactive Oxygen SpeciesSignal TransductionActinsNADPH OxidasesReactive Oxygen Species

Identifiers

PMID19737088
PMCPMC2829046
OpenAlexW2067413723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.