ReviewThe Journal of physiology2009
Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases.
Review in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Genes to predict VOBMC genomics · 2017Pooled it
- Impact of resistance and high-intensity interval training on body composition, physical function, and temporal dynamics of adaptation in older women with impaired cardiometabolic health: a randomized clinical trial.BMC sports science, medicine & rehabilitation · 2025Article
- Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults.Journal of cardiovascular development and disease · 2025Article
- The effects of high-intensity interval training/moderate-intensity continuous training on the inhibition of fat accumulation in rats fed a high-fat diet during training and detraining.Lipids in health and disease · 2024Article
- Effect of exercise engagement and cardiovascular risk on neuronal injury.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of MACROD2 gene variants with obesity and physical activity in a Korean population.Molecular genetics & genomic medicine · 2021Article
- Differences in the Anthropometric and Physiological Profiles of Hungarian Male Rowers of Various Age Categories, Rankings and Career Lengths: Selection Problems.Frontiers in physiology · 2021Article
- The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.Journal of lipid research · 2020Article
- Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men.International journal of molecular sciences · 2018Article
- Comparing Time Efficiency of Sprint vs. High-Intensity Interval Training in Reducing Abdominal Visceral Fat in Obese Young Women: A Randomized, Controlled Trial.Frontiers in physiology · 2018Article
- Circulating protein synthesis rates reveal skeletal muscle proteome dynamics.The Journal of clinical investigation · 2016Article
- Elite athletes' genetic predisposition for altered risk of complex metabolic traits.BMC genomics · 2015Article
- Changes in Physiological Parameters after Combined Exercise according to the I/D Polymorphism of hUCP2 Gene in Middle-Aged Obese Females.Iranian journal of public health · 2014Article
- Metabolic programming of adipose tissue structure and function in male rat offspring by prenatal undernutrition.Nutrition & metabolism · 2014Article
- Sensation-seeking genes and physical activity in youth.Genes, brain, and behavior · 2013Article
- Educational differences in self-rated physical fitness among Finns.BMC public health · 2013Article
- Relationship of body fat and cardiorespiratory fitness with cardiovascular risk in Chinese children.PloS one · 2011Article
- Inter-individual variability in the improvement of physiological risk factors for disease: gene polymorphisms or simply regression to the mean?The Journal of physiology · 2010Article
- Physiological regulation linked with physical activity and health.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Habitual exercise training, including a high-intensity interval walking programme, improves cardiorespiratory fitness and alleviates lifestyle-related diseases, such as obesity, hypertension and dyslipidaemia. However, the extent of improvement has been shown to differ substantially among individuals for various exercise regimens. A body of literature has demonstrated that gene polymorphisms could account for the inter-individual variability in the improvement of risk factors for lifestyle-related diseases following exercise training. However, the fractions of the variability explained by the polymorphisms are small (5%). Also, it is likely that the effects of gene polymorphisms differ with exercise regimens and subject characteristics. These observations suggest the necessity for further studies to exhaustively identify such gene polymorphisms. More importantly, the physiological and molecular genetic mechanisms by which gene polymorphisms interact with exercise to influence the improvements of risk factors for lifestyle-related diseases differentially remain to be clarified. A better understanding of these issues should lead to more effective integration of exercise to optimize the treatment and management of individuals with lifestyle-related diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.