ArticleGenome biology2009
A global survey identifies novel upstream components of the Ath5 neurogenic network.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 32 citations in OpenAlex.
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- De novo neurogenesis by targeted expression of atoh7 to Müller glia cells.Development (Cambridge, England) · 2016Article
- Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish.Development (Cambridge, England) · 2016Article
- TRIM25 has a dual function in the p53/Mdm2 circuit.Oncogene · 2015Article
- A trans-Regulatory Code for the Forebrain Expression of Six3.2 in the Medaka Fish.The Journal of biological chemistry · 2015Article
- Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway.BMC biotechnology · 2015Article
- Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.The EMBO journal · 2015Article
- Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling.EMBO reports · 2014Article
- The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.Journal of cell science · 2014Article
- Differential responsiveness of distinct retinal domains to Atoh7.Mechanisms of development · 2014Article
- Evolutionary relationships and diversification of barhl genes within retinal cell lineages.BMC evolutionary biology · 2011Article
- De novo genesis of enhancers in vertebrates.PLoS biology · 2011Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvestigating the architecture of gene regulatory networks (GRNs) is essential to decipher the logic of developmental programs during embryogenesis. In this study we present an upstream survey approach, termed trans-regulation screen, to comprehensively identify the regulatory input converging on endogenous regulatory sequences.
resultsOur dual luciferase-based screen queries transcriptome-scale collections of cDNAs. Using this approach we study the regulation of Ath5, the central node in the GRN controlling retinal ganglion cell (RGC) specification in vertebrates. The Ath5 promoter integrates the input of upstream regulators to enable the transient activation of the gene, which is an essential step for RGC differentiation. We efficiently identified potential Ath5 regulators that were further filtered for true positives by an in situ hybridization screen. Their regulatory activity was validated in vivo by functional assays in medakafish embryos.
conclusionsOur analysis establishes functional groups of genes controlling different regulatory phases, including the onset of Ath5 expression at cell-cycle exit and its down-regulation prior to terminal RGC differentiation. These results extent the current model of the GRN controlling retinal neurogenesis in vertebrates.
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