ArticleFEMS microbiology letters2009
Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA.
Article in FEMS microbiology letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 129 citations in OpenAlex.
- Natural 2-phenyl chroman flavonoids against Streptococcus mutans: prospects of herbal remedies for dental caries.Journal of materials science. Materials in medicine · 2026Review
- Innovations in process engineering approaches for enhanced bacteriocin production.Journal of industrial microbiology & biotechnology · 2026Review
- N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque.NPJ biofilms and microbiomes · 2025Article
- A novel insight into ComE-mediated activation of gene expression inMicrobiology spectrum · 2025Article
- Deciphering the role of SMU.1147 in peptide-mediated signaling and competence inMicrobiology spectrum · 2025Article
- Examination of the Structure and Formation Streptococcus mutans Biofilm Induced by Glucose, Lactose, Soy Protein, and Iron.European journal of dentistry · 2024Article
- ComprehensiveFrontiers in microbiology · 2024Article
- Antimicrobial Efficiency of Chitosan and Its Methylated Derivative againstMolecules (Basel, Switzerland) · 2022Article
- Article
- Distinct Agents Induce Streptococcus mutans Cells with Altered Biofilm Formation Capacity.Microbiology spectrum · 2022Article
- Inhibitory Effect ofMedicina (Kaunas, Lithuania) · 2021Article
- The dental plaque biofilm matrix.Periodontology 2000 · 2021Review
- Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.Nature microbiology · 2021Article
- Understanding the Matrix: The Role of Extracellular DNA in Oral Biofilms.Frontiers in oral health · 2021Review
- Antimicrobial antidegradative dental adhesive preserves restoration-tooth bond.Dental materials : official publication of the Academy of Dental Materials · 2020Article
- Rapid Isolation and Purification of Secreted Bacteriocins fromBio-protocol · 2020Article
- Competence-Stimulating-Peptide-Dependent Localized Cell Death and Extracellular DNA Production in Streptococcus mutans Biofilms.Applied and environmental microbiology · 2020Article
- Modulation of Lipoteichoic Acids and Exopolysaccharides PreventsMolecules (Basel, Switzerland) · 2020Article
- Peptides encoded in theMicrobiology (Reading, England) · 2020Article
- Proteolytic Activity ofMicroorganisms · 2020Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcal competence-stimulating peptides (CSPs) were once thought to passively communicate population density in a process known classically as quorum sensing. However, recent evidence has shown that these peptides may also be inducible 'alarmones,' capable of conveying sophisticated messages in a population including the induction of altruistic cellular suicide under stressful conditions. We have previously characterized the alarmone response in Streptococcus mutans, a cariogenic resident of the oral flora, in which a novel bacteriocin-like peptide causes cell death in a subset of the population. Our objective in this work was to characterize the mechanism of immunity to cell death in S. mutans. Toward this goal, we have identified the conditions under which immunity is induced, and identified the regulatory system responsible for differential (and protective) expression of immunity. We also showed that CSP-induced death contributes to S. mutans biofilm formation through the release of chromosomal DNA into the extracellular matrix, providing a long sought-after mechanistic explanation for the role of CSP in S. mutans biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.